Enzyme-catalyzed [4+2] cycloaddition is a key step in the biosynthesis of spinosyn A. Nature 473, 109–112 (2011). Article CAS PubMed PubMed Central Google Scholar Partel, A. et al. Dynamically complex [6+4] and [4+2] cycloadditions in the biosynthesis of spinosyn A. J. Am. ...
Luciferase is an enzyme that produces bioluminescence via the oxidation of a substrate, often referred to as luciferin. Many species of bacteria and eukaryotes make luciferases natively. While molecular oxygen is a common required component, the chemical reactions and regulatory mechanisms underlying biol...
N-Acetyl-β-glucosaminidase is an enzyme found in urine, specifically derived from the proximal tubule, which is released when epithelial cells of the tubule are damaged or die. AI generated definition based on: Biomarkers in Toxicology, 2014 ...
Given the exposure to harsh environments, the microbial chassis selected for off-world biomanufacturing must have high adaptability to various stress conditions. Notably,Rhodococcusis distinguished by its remarkable catabolic versatility and resistance to stressful environmental conditions, making it a widely ...
The biochemical and clinical perspectives of Lactate dehydrogenase: an enzyme of active metabolism. Endocr Metab Immune Disord Drug Targets. 2020;20(6):855–68. CAS PubMed Google Scholar Fujimoto N, Kitamura S, Uramaru N, Miyagawa S, Iguchi T. Identification of hepatic thyroid hormone-...
Intrinsic metabolism shapes the immune environment associated with immune suppression and tolerance in settings such as organ transplantation and cancer. However, little is known about the metabolic activities in an immunosuppressive environment. In this
(SOCS-3) with the IL-12R receptor to attenuate Th1 cytokine production. Furthermore, PIBF inhibits the cytological activity (natural killer) of NK cells by blocking perforin and lytic enzyme degranulation. Finally, PIBF interacts with B cells, increasing the production of asymmetric antibodies. All...
[27] or chemical treatment (e.g., the addition of surfactant Silwet L-77) [26] to achieve high cellular transformation efficiency could induce innate immunity and stress responses in plants, which globally alters cellular, physiological, and signaling processes and severely retards growth [28, 29...
An enzyme activator is a substance that can enhance the activity of an enzyme, leading to an increase in the rate of a specific biochemical reaction. AI generated definition based on: Advances in Heterocyclic Chemistry, 2018 About this pageSet alert ...
Genetic inactivation of this enzyme abrogated resistance [273]. This observation identifies a new opportunity for adjuvant identification. Polymyxin as an antibacterial adjuvant. Many structures show in vitro synergy with the polymyxins. A combination of polymyxin B with 13 different antibiotics against ...