2016,Kaufman's Atlas of Mouse Development Supplement Chapter Connective and Soft Tissues 4.4.1The Skin The skin (also called theintegument) is one of the largest organs in humans on a volume basis. There are di
(TEBs). The female mouse is considered a mature virgin after 8weeks. Only in concomitance with the gestation and thelactationdoes the alveolar proliferation and the functional differentiation ofalveolar cellsoccur. After weaning, the mammary gland undergoes the involution process to restore a simple...
The cumulative number of stem cell divisions in a tissue, known as mitotic age, is thought to be a major determinant of cancer-risk. Somatic mutational and DNA methylation (DNAm) clocks are promising tools to molecularly track mitotic age, yet their rela
Ductal carcinoma in situ (DCIS) of the breast is a non-obligate precursor of Invasive Ductal Carcinoma (IDC) and thus the identification of features that may predict DCIS progression would be of potential clinical value. Experimental mouse models can be
In colorectal cancer, knockdown of ELF3 in HCT116 cells induced ZEB1 upregulation. ELF3 expression was found to antagonize ZEB1 expression by inhibiting the Wnt and RAS oncogenic signalling path- ways [28]. Consistent reports in non-transformed mouse mammary gland epithelial cell line (NMuMG) ...
α3β1 integrin, are necessary for mammary tumo- rigenesis [21], α2β1 integrin (a receptor for collagen and other matrix molecules that highly expresses in normal breast epithelium) is a metastasis suppressor (but with little impact on primary tumor growth) in a mouse model of BCa [22]...
born when only 16 to 17 mm long and weighing about 440 mg at a developmental stage roughly equivalent to a 40-day human or 15-day mouse embryo. The kidney bean-sized newborn has well-developed forelimbs that allow it to climb up to the mother's pouch, where it attaches to one of ...
tissue maps such as an atlas of mouse hypothalamic preoptic region [158] (Fig.3). Fig. 3 Spatial transcriptomics of organoids. In spatial transcriptomics, a tissue section is positioned on a slide covered with an array of cells containing reagents for a subsequential cell lysis and barcoding....
For example, scCATCH [10] built a reference database “CellMatch” combining databases CellMarker [11], Mouse Cell Atlas (MCA) [12], CancerSEA [13], and the CD Marker Handbook [14]. SCSA [15] integrated databases from CellMarker and CancerSEA. Some of these databases (e.g., MCA) ...
The female mouse normally has five pairs of mammary glands, three in the cervicothoracic region and two in the inguinoabdominal region. Detailed techniques for manipulating gametes and embryos have been developed (Daniel, 1978). The male reproductive organs consist of paired testes, urethra, ...