Ruth Bellairs, Mark Osmond, in Atlas of Chick Development (Third Edition), 2014 The Urinary System With the exception of the cloaca and the primordial germ cells, the urino-genital system is derived from the intermediate mesoderm which lies between the somites and the lateral plate, to both ...
Expression of the mouse Tekt2 gene was observed only in testis during the postmeiotic period. The protein was detected by immunohistochemistry in elongating spermatids and was localized to the flagellum of spermatozoa (376). The human TEK2 gene was found to be expressed at the highest level in...
For example, scCATCH [10] built a reference database “CellMatch” combining databases CellMarker [11], Mouse Cell Atlas (MCA) [12], CancerSEA [13], and the CD Marker Handbook [14]. SCSA [15] integrated databases from CellMarker and CancerSEA. Some of these databases (e.g., MCA) ...
Here we build and validate a pan-tissue epigenetic counter of total mitotic age called stemTOC (Stochastic Epigenetic Mitotic Timer of Cancer) that addresses the above challenges, and subsequently apply it in conjunction with a DNAm atlas and advanced cell-type deconvolution methods37,38, to demon...
Ductal carcinoma in situ (DCIS) of the breast is a non-obligate precursor of Invasive Ductal Carcinoma (IDC) and thus the identification of features that may predict DCIS progression would be of potential clinical value. Experimental mouse models can be
Upregulation of the PD-L1 (CD274) immune checkpoint ligand on the tumor surface facilitates tumor immune escape and limits the application of immunotherapy in various cancers, including breast cancer. However, the mechanisms underlying high PD-L1 levels
published a report on the oncogenic properties of YAP1, which had been identified through a screen for copy number changes in mouse mammary tumours. Interestingly, the genetic background used for screening was the Brca1/Trp-53 which in the majority of cases gives rise to ER- mammary tumours ...
Expression patterns of mouse genes encoding proteins with catalytic activity Under its "Molecular Function" category, Gene Ontology lists approximately 2700 gene products that exhibit activity associated with catalysis [22]. We have determined the expression patterns of 662 of the 2700 mRNAs in E14.5 ...
As a first attempt to gather animals in categories, we can consider (i) wild (e.g., opossum, armadillo, raccoon, rat, mouse) or domestic (e.g., dog, cat, guinea pig; see Chapter 11) animal species known to have a potential role in the epidemiology of the disease; (ii) wild (e...
In Knottenbelt and Pascoe's Color Atlas of Diseases and Disorders of the Horse (Second Edition), 2014 Placentitis (Figs. 12.72–12.77) Placentitis, an inflammation of the placenta, is usually caused by an infectious agent, most commonly bacteria. These organisms gain access to the placenta ...