After only 3 days of administration, macrolides may seriously reduce digoxin metabolism in the gastrointestinal tract by Eubacterium lentum, resulting in digitalis toxicity because the microorganism may metabolize 30% to 40% of the drug. Macrolides may potentiate the anticoagulant effect of oral anticoa...
Heparin sulfate derivatives and its mimics are possible inhibitors but can potentially act as an anticoagulant. With an objective of safe heparanase inhibitors without anticoagulant properties some glycoconjugates were developed. Phosphomannopentaose sulfate (109 PI-88, Muparfostat) (Fig. 19) is a ...
Tissue factor pathway inhibitor (TFPI) is an anticoagulant that inhibits blood coagulation pathway enzymes VIIa and Xa. This inhibition leads to reduced fibrin formation1,2,3,4. Thus, increasing the TFPI levels in plasma should be useful in controlling thrombosis. The TFPI levels are due to its...
So far, some interesting coumarin-based anticoagulant drugs have extensively been used in clinics [29]. Coumarins are a type of vitamin K antagonists [30]. The most notable ones are warfarin, acenocumarol, and phenprocoumon, currently in use in several countries [31, 32]. Warfarin is ...
Triterpene glycosides exhibit different bioactivities, which might aid the likelihood of survival for its producing organisms. This is also highlighted by their broad bioactivities as well as their broad ecological functions (e.g., antipredatory defense). Although the structure of each unit affects the...
Solute carrier organic anion transporter 1B3 (SLCO1B3) is an important liver primarily highly expressed gene, its encoded protein (OATP1B3) involved in the transport of multi-specific endogenous and exogenous substances. We previously reported that an EA
In the European regulatory framework, Tregcells enriched by immunoselection are not considered as a medicinal product and are regulated under the European Union Tissue and Cells Directive 2004/23/EC [26]. Instead, Tregcells expanded ex vivo are classified as an ATMP, which is a substantially man...
Rhipicephalus sanguineus, known as the brown dog tick, is a common ectoparasite of domestic dogs and can be found worldwide. R. sanguineus is recognized as the primary vector of the etiological agent of canine monocytic ehrlichiosis and canine babesiosis
It is found in India, Bangladesh, Sri Lanka, Iran, Pakistan, and the Moluscan Islands. Although practically all of its components are used in traditional medicine, the roots, stems, and leaves are all utilized. It has become well-known traditional medicinal herb with widespread use in Unani,...
S. gordonii was classified as S. sanguinis serotype II in the past. However, S. gordonii lacks the IgA1 protease. It is a gram-positive coccus (Figure 3.14(A)–(C)). The cell wall components are mainly glycerol, teichoic acid, and rhamnose, while its peptidoglycan type is Lys–Ala. ...