An Abnormal Elevation of Hemoglobin A2 in Hereditary Spherocytosisdoi:10.1093/ajcp/47.4.454Harmeling James G.Moquin Ross B.With the Technical Assistance OkSellers William H.American Journal of Clinical Pathology
Hemoglobin S (p. 57) is an abnormal protein resulting from a point mutation (transversion) in the gene encoding for the globin β chain. An adenine is substituted by thymine, resulting in a change in the glutamic acid (GAA) codon, for valine (GUA). In this case, a single amino acid...
Studies on an abnormal minor hemoglobin component (Hb-B2). Clin Chim Acta. 1961;6:246-253.Horton , B. (F.), R. A. Payne , M. T. Bridges and T. H. J. Huisman : Studies on an Abnormal Minor Hemoglobin Component (Hb-B 2 ). Clin. Chim. Acta 6 , 246 (1961)....
On the sixth day of the kidney biopsy, she developed severe clinical signs of acute bleeding complication (Fig. 2) and was transferred to the intensive care unit. Because of life-threatening anemia (hemoglobin of 26 g/l), she got six doses of blood transfusion, and the left kidney was ...
age 40 to 80 years; body weight 45 to 110 kg; body mass index (calculated as weight in kilograms divided by height in meters squared) 18 to 34; postmenopausal, surgically sterile, or using adequate contraception; and no history of significant cardiac disorders or abnormal magnetic resonance ima...
No abnormal physical signs were noted but the patient was referred to the neurological department. The history of generalised pains in the body and of pain in the right hip and right leg, together with sensations of pins and needles, was repeated. There were no abnormal neurological signs ...
Laboratory abnormalities included elevated liver chemistries, elevated creatine phosphokinase, elevated creatinine, and lymphopenia, and abnormal chest x-ray findings (predominantly infiltrates, which were localized). Additional Adverse Reactions with Use of TRIZIVIR Treatment-emergent clinical adverse reactions ...
GDM is one of the most common complications of pregnancy and is defined as the first occurrence of diabetes during pregnancy due to abnormal glucose metabolism [7,10]. The International Diabetes Federation estimates that the global prevalence of diabetes will increase to 10.2 percent (578 million ...
Hemoglobin can be extracted from red blood cells by removing the cell membranes to form stroma-free hemoglobin. Attempts in clinical trials in patients to use stroma-free hemoglobin as blood substitute have not been successful, because of renal toxicity and other adverse effects [14]. When infused...
Hereditary causes of methemoglobinemia are rare and include mutations in the gene for NADH-cytochrome b5 reductase 3 (CYB5R3), resulting in a diminished capacity to reduce methemoglobin, and mutations in the α-, β-, or γ-globin gene, resulting in a structurally abnormal polypeptide chain ...