Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that is marked by fasciculation, spasticity and progressive weakness of muscles, and results in difficulty speaking, swallowing and breathing. ALS is fatal, usually leading to death within a few years from diagnosis, although...
AMYOTROPHIC lateral sclerosisTELOMERASEGENE expressionNEUROLOGYLEUCOCYTESNEURODEGENERATIONPATIENTSTelomerase and telomeric complex have been linked to a variety of disease states related to neurological dysfunction. In amyotrophic lateral sclerosis (ALS) patients, telomerase activity, as human telomerase reverse ...
肌萎缩侧索硬化症(amyotrophic lateral sclerosis,ALS) ,俗称“渐冻人症”,是一种以大脑和脊髓运动神经元退行性改变为特征的进行性麻痹性疾病,通常以隐匿性的局部无力起病,然后快速进展至包括膈肌在内的多数肌肉麻痹。 ALS临床表现因受累及存活运动神经元的不同而存在较大的异质性,典型症状为四肢无力起病,但有大约1...
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s Disease, is an uncommon neurological disorder that primarily impacts motor neurons. As the name suggests, these are nerve cells situated in the brain and spinal cord responsible for governing voluntary muscle movements, such as walking...
名称来源:ALS的学名来源于希腊文“amyotrophia”:其中“a-”表示“不”,“myo”指“肌肉”,trophia意思是“营养”;因此“amyotrophia”表示“没有肌肉营养”,描述了患者肌肉组织的萎缩特征。脊髓横向识别领域是受影响的神经细胞所在部位。在这一地区的退化会导致疤痕或硬化。
【题目】41 A Amyotrophic lateral sclerosis(ALS)(肌萎缩性侧索硬化症) is a progressiv e neurodegenerat iv e diseas e that affects nerv e cells in th e bra in an d th e spinal cor d. Motor neurons reach f rom th e brain to th e spinal cor d an d from the spinal cor d to ...
ALS 患者治疗过程中,应注重多科协作,涉及神经科、呼吸内科、消化内科、心理科、康复科、营养科等,护理人员在其中也发挥着重要作用。 八、诊疗流程 作者 北京协和医院神经内学科 刘明生 参考文献 [1] Brown RH,Al-Chalabi A.Amyotrophic Lateral Sclerosis.N Engl J Med,2017,377(2):162-172. ...
Amyotrophic lateral sclerosisis a progressiveneurodegenerative diseasethat usually results in death within 3 to 5years of diagnosis.158, 159The prevalence ofALSis estimated at 4.3 cases per 100,000.160A small percentage (5%-10%) of patients with ALS have familial ALS (fALS), or heredit...
(6分)Amyotrophic lateral sclerosis, more commonly known as ALS, affects the nerve cells in the brain and spinal cord (脊髓) that make the muscles of both the upper and lower body work. Those nerve cells lose their ability to control muscle movement, which leads to paralysis (瘫痪) and ...
由于上位运动神经元变性,脊髓侧索中的皮质脊髓束的轴索消失和萎缩,髓鞘染色其部位浅染。前角和脑神经运动核的下位运动神经元变性,其结果前根或运动神经的轴索消失、萎缩,变成白色。这些神经元支配的骨骼肌中,产生广泛的神经源性的肌纤维萎缩。此病病因及发病机制尚不清楚。 左图为HE染色,可见脊髓的两侧侧索因变性而...