Amyloidosis is a buildup of abnormal proteins in your tissues and organs. Explore the symptoms and treatments of this rare but serious disease.
Amyloid proteins can build up for a long time before causing any symptoms, so the disease usually is not diagnosed until it is well established. Because the symptoms associated with amyloidosis are common to several different diseases, your doctor may run many different tests to check for other ...
Amyloid protein is deposited in different organs and sites and affects the performance of the site where it is deposited. Depending on which organs are affected and the degree to which organ function is affected, symptoms of amyloid light chain amyloidosis will vary. Initially, the symptoms can ...
signs and symptomspurpuramacroglossiadiagnosisdrug therapytreatmentoutcomePrimary amyloidosis is a plasma cell dyscrasia in which insoluble immunoglobulin light chain fragments are produced and polymerize into fibrils that deposit extracellularly, causing visceral organ dysfunction and death. The disorder is ...
Learn about the causes and symptoms of ATTR amyloidosis, a rapidly progressive, debilitating disease caused by misfolded transthyretin (TTR) protein.
When the patient has 20% to 30% plasma cells, do you treat it as myeloma or as amyloidosis? You make that decision by looking at the symptoms. — Jonathan L. Kaufman, MD Tweet this quote Dr. Kaufman also advised doing a fat pad aspirate and/or bone marrow biopsy...
Constitutional symptoms such as weight loss and fatigue are common and can further help distinguish amyloidosis from other etiologies of neuropathy. The pathologic hallmark of amyloidosis is the presence of a homogeneous amorphous substance that stains pink with H&E and demonstrates apple-green ...
An isoleucine 122 gene mutation of the TTR DNA causes a familial amyloidosis primarily involving the heart without neurologic symptoms and is unique to elderly black persons. It is estimated that 1.3 million black persons are heterozygous for isoleucine 122.18 Presentation of the phenotype is...
Presenting symptoms include chronic cough, dyspnea, and recurrent pneumonias, which overlap with symptoms from congestive heart failure. The most common mechanism of pathophysiology is the obstruction of bronchi or bronchioles owing to interstitial wall thickening or mass effect because of a large focal...
For something that can be so serious, the symptoms of amyloidosis can be a tricky thing to deal with. Many are very subtle. Some are common issues which can be the symptoms of many other conditions. Only a doctor can make a proper diagnosis on amyloidosis. Some of the symptoms they will...