Over the 23-month course of this project, 142 PYP scans were ordered of which 18 were equivocal or positive. The number of ordering providers increased from 7 prior to the protocol's implementation to 22 by the end of this project within 23 months. On change point analysis, PYP scan ...
TC-PYP scan, or scintigraphy using hydroxy diphosphonate or diphosphonate (DPD), are affordable and highly accurate methods to confirm the diagnosis of ATTR-CM. However, confirmatory testing with 99mTc-PYP imaging [79] and recommended monoclonal protein evaluation before PYP scanning [80] remain ...
AHL Amyloidosis Mimicking ATTR on Cardiac PYP Scan: A Diagnostic Challenge Journal of Nuclear CardiologyTing-Jui HsuChin-Te TsengLing KuoChih-Yu YangYao-Ping LinWen-Chung YuDer-Cherng Tarng
The protocol for this systematic review is registered on the international prospective register of systematic reviews (PROSPERO) from the National Institute for Health Research Database (www.crd.york.ac.uk/prospero; protocol no. CRD42022310956), and the PRISMA statement was adhered to [12]. An el...
cardiac MRI or PYP scan was considered to be diagnostic and the date of whichever study came first defined as the diagnosis date. For cases where providers noted a strong suspicion of amyloidosis on TTE before subsequent confirmation by another modality, the date of the TTE was recorded as the...
A 99mTc-PYP scan showed grade 3 myocardial uptake, H/CL ratio of 1.8 at 3 h (A) confirmed by SPECT (B). He was diagnosed with wild-type ATTR-CM. Error: Diagnosis of ATTR-CM based on cardiac scintigraphy in the setting of an abnormal sFLC ratio without hematology consultation. Correct...
PYP: Pyrophosphate Tc: 99mTechnetium References Child JS, Levisman JA, Abbasi AS, MacAlpin RN. Echocardiographic manifestations of infiltrative cardiomyopathy. A report of seven cases due to amyloid. Chest 1976;70:726-31. Article CAS PubMed Google Scholar Braun SD, Lisbona R, Novales-Diaz...
330 Echocardiographic Parameters Predictive of a Positive 99mTc-PYP Scan in Patients with Suspected Cardiac ATTR-Amyloidosisdoi:10.1016/j.hlc.2020.09.337S. MeierB. DavisC. YuG. YungC. NaoumHeart, Lung and Circulation
In particular, the scan duration correction was applied considering the actual frame duration of the early (AFDE) and late (AFDL) images, as reported in the DICOM header. The decay correction accounted for the 99mTc physical decay between the early and late image scan acquisition times (Δ𝑡...