Blood Protein Markers of Neocortical Amyloid-beta Burden: A Candidate Study Using SOMAscan Technology. J Alzheimers Dis 46, 947-961, doi: 10.3233/JAD-150020 (2015).Voyle N, Baker D, Burnham SC, Covin A, Zhang Z, Sangurdekar DP, Tan Hehir CA, Bazenet C, Lovestone S, Kiddle S, ...
背景说明: Serum Amyloid A1 Protein (SAA1) is an acute phase apolipoprotein reactant that is produced predominantly by hepatocytes and is under the regulation of inflammatory cytokines. SAA is produced mainly in the liver and circulates in low levels in the blood. SAA may play a role in the...
Alzheimer’s disease (AD) is a prevalent neurodegenerative disease and the world’s primary cause of dementia among the elderly population. The aggregation of toxic amyloid-beta (Aβ) is one of the main pathological hallmarks of the AD brain. Recently, n
Tau protein and its role in blood–brain barrier dysfunction. Front. Mol. Neurosci. 2020, 13, 570045. [Google Scholar] [CrossRef] [PubMed] Jiang, T.; Yu, J.-T.; Tian, Y.; Tan, L. Epidemiology and etiology of Alzheimer’s disease: From genetic to non-genetic factors. Curr. ...
Amyloid precursor protein (APP) is a transmembrane protein that is synthesized in the endoplasmic reticulum and plays a major role in synaptic development, mineral transfer, neuronal plasticity, and regulation of cell signaling in neuronal tissues. Mutations in APP are responsible for the early onset...
et al. Clearance of Alzheimer's amyloid-β1–40 peptide from brain by LDL receptor-related protein-1 at the blood–brain barrier. J. Clin. Invest. 106, 1489–1499 (2000). Article CAS PubMed PubMed Central Google Scholar Cirrito, J. R. et al. In vivo assessment of brain ...
Serum amyloid A (SAA) is a famous acute-phase protein and essential in the immune-mediated inflammatory process. SAA is demonstrated to be a promising biomarker in various immune-related diseases. Accumulative evidence show that SAA may participate in the pathogenesis of inflammatory bowel disease. ...
(e.g., on anticoagulants) or increased intracranial pressure. Blood biomarkers have shown potential for high diagnostic performance in a minimally invasive manner14,15,16, but have not been applied in routine clinical practice17. Meanwhile, magnetic resonance imaging (MRI) has achieved widespread ...
Literatur. Mollison PL, Engelfriet CP (1993) Blood transfusion in cli- nical medicine. Blackwell Scientific Publications, London Mueller-Eckhardt C, Kiefel V (2003) Transfusionsmedizin. Springer, Berlin Heidelberg New York Acrosomal serine protease inhibitor 7 Protein-C-Inhibitor ACT 7 α1-...
(n = 103) by using the Latex Enhanced Immunoturbidimetric Method and IHC, respectively. The Scatter plots show a positive correlation between the levels of peripheral blood SAA and peritumoral SAA expression.e–hDynamic monitoring of blood SAA indicated that SAA could be a potential ...