Beta-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease: implications for the physiological function of HtrA2 in the mitochondria. J Biol Chem, 2006, 281(45): 34277-34287Beta-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease. Implications ...
This cleavage shears off the bulk of the extracellular domain of APP, which then allows the protein to be cleaved within the membrane by γ-secretase. Intramembrane cleavage can occur at either of the two sites separated by two amino acids, leading to two different amyloid β peptides...
Abeta peptide is 40-43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease, beta-secretase (...
Amyloid β-peptide (1-40) (rat) 是蛋白水解切割淀粉样蛋白前体蛋白的易聚集产物,并且是在阿尔茨海默病脑中观察到的老年斑的主要成分。Amyloid β-peptide (1-40) (rat) is the prone-to-aggregation product of amyloid precursor protein proteolytic cleavage, and is the major constituent of senile plaques...
23 December 2016 Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway Shao Li1,2, Xi Wang1,3, Quan-Hong Ma4, Wu-lin Yang2, Xiao-Gang Zhang1, Gavin S. Dawe2,5,6 & Zhi-Cheng Xiao3,7 Amyloid precursor protein (APP), co...
Aberrant cleavage of amyloid precursor protein (APP) by γ-secretase contributes to the development of Alzheimer's disease. More than 200 disease-derived mutations have been identified in presenilin (the catalytic subunit of γ-secretase), making modulation of γ-secretase activity a potentially attrac...
aManwomAn^ ManwomAn^ [translate] aderived from the sequential cleavage of the amyloid precursor protein [translate] 英语翻译 日语翻译 韩语翻译 德语翻译 法语翻译 俄语翻译 阿拉伯语翻译 西班牙语翻译 葡萄牙语翻译 意大利语翻译 荷兰语翻译 瑞典语翻译 希腊语翻译 51La ...
(synchronous precursor selection [SPS]) for an MS3spectrum with reporter ion quantification. Half-tryptic peptides for cleavage by γ-Secretase were detectable at less than 200 amol, while the half-tryptic peptide for cleavage of Aβ peptides by BACE1 could be detected at 600 amol (Fig.4d)...
Observation of amyloid precursor protein cleavage and Aβ generation in living cells by using multiphoton laser scanning microscopy Hua-Jing Yang,Zhi-Hong Zhang.Observation of amyloid precursor protein cleavage and Aβ generation in living cells by using multiphoton laser scanning ... XQ Li,SM Zhang...
Presenilin 1 (PS1) plays a pivotal role in the production of the amyloid-β protein, which is central to the pathogenesis of Alzheimer's disease. It has been demonstrated that PS1 regulates the γ-secretase proteolysis of the amyloid precursor protein (APP) C-terminal fragment (APP-C100), ...