Dementia was present in 64% of 28 cases with many NFTs, while it was present only 33% of 43 cases in which there were many SPs but a few NFTs. The rate of prevalence of β-immunoreactive SPs increased with age in both demented and non-demented subjects. It was not significantly ...
“Most of us will accrue amyloid plaques in our brains as we age, and yet very few of us with plaques go on to develop dementia,” said Espay, professor of neurology in the UC College of Medicine and director and endowed chair of the James J. and Joan A. Gardner Family Center f...
Schmidt ML, Lee VM, Saido T, Perl D, Schuck T, Iwatsubo T, Trojanowski JQ (1998) Amyloid plaques in Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex contain species of A beta similar to those found in the amyloid plaques of Alz- heimer's disease and pathological aging. Acta...
Abeta is an extracellular filamentous protein component of amyloid cores, neuritic plaques and is also found as a deposit in neurofibrillary tangles. Alzheimer’s disease, the most common cause of senile dementia, is characterized by abnormal filamentous protein deposits in the brain. Beta amyloid ...
Alterations of amino acids in older adults with Alzheimer’s Disease and Vascular Dementia Xin Ma Xin-Meng Wang Jiang-Ning Zhou Amino Acids (2025) Neuroinflammation in Alzheimer’s disease: insights from peripheral immune cells Qiang Zhang Guanhu Yang Gang Tian Immunity & Ageing (2024) Mis...
Alzheimer's disease, the most common type of senile dementia, is characterised by p-amyloid plaques, neurofibrillary tangles and neuronal loss. Amyloid plaques are associated with the increased inflammation and oxidative stress. Rodent m... AM Falinska - 《Cardiff University》 被引量: 0发表: 2004...
Alzheimer disease (AD) is the most common type of dementia, and is currently incurable; existing treatments for AD produce only a modest amelioration of symptoms. Research into this disease has conventionally focused on the CNS. However, several peripheral and systemic abnormalities are now understood...
1, 2 However, the time course and severity of AD dementia have been generally found to correlate with neurofibrillary tangle development rather than plaque appearance,3, 4, 5, 6, 7, 8 although a few studies have linked plaques with early cognitive decline.9, 10, 11, 12 Soluble oligomeric ...
The principal pathological features of Alzheimer's disease (AD), comprised of neurofibrilary tangles and amyloid plaques, are posited by the amyloid cascade hypothesis [1–3] to be pivotal in the clinical manifestations (impaired memory and cognition, dementia) of the disease. Current marketed ther...
et al. Pre-dementia clinical stages in presenilin 1 E280A familial early-onset Alzheimer's disease: a retrospective cohort study. Lancet Neurol. 10, 213–220 (2011). Article CAS PubMed Google Scholar Godbolt, A. K. et al. The natural history of Alzheimer disease: a longitudinal ...