Amyloid PET scansMCIbiomarkersdementiadisclosureObjectives To explore patient and care partner experiences of receiving an amyloid scan result, with a focus on how clinician disclosure practices influenced patient and care partner emotional responses to the scan result and/or diagnosis. Methods Semi-...
This participant-level meta-analysis estimates the prevalence of PET scan–measured amyloid in Alzheimer disease participants and its associations with
Over two-thirds (68.1%) had an elevated amyloid-β PET scan. Mean COC for all patients was 0.154 (SD = 0.102; range = 0–0.73) prior to the scan and 0.158 (SD = 0.105; range = 0–1.0) in the year following the scan. Following the scan, the mean COC index score increased (95...
A Positive Amyloid PET Scan Identifies Subtle Cognitive Problems in Asymptomatic Adults"I hope these compelling findings will motivate more of my basic science colleagues to start investigating klotho, its protein network partners, and its potential interactions with APOE," said Dr. Greicius. In ...
Conclusions Florbetapir-PET imaging performed during life in this study correlated with the presence and density of β-amyloid at autopsy. This prospective imaging to autopsy study provides evidence that a molecular imaging procedure can identify β-amyloid pathology in the brains of individuals during ...
After the induction of anesthesia, the animals were positioned with their heads in the center of the field of view and were fixed in the PET scanner in the prone head first position (HFP). At the beginning of the PET scanning procedure, computed tomography (CT) scans were acquired for ...
A total of 28 patients were acquired in both PET/CT and CMB scans using amyloid tracers. Because of the axial field of view of 150 mm and the use of external anatomical references for patient positioning, the cerebellum was not completely included in the CMB PET scan in 2 studies, ...
The capacity of plasma AβO was found for identifying abnormal amyloid PET scan before AD or MCI. For validation of analyses, the plasma AβO levels were calculated using multiple approaches (as a ratio or concentration) for each participant. This study does have some limitations. First, ...
We also examined early regional Aβ accumulation in the presumably earliest Aβ accumulators; those with normal CSF Aβ42 and normal Aβ PET at baseline who converted to abnormal CSF Aβ42 levels at follow-up but still had a normal Aβ levels identified by PET scan (CSF−/PET to CSF+...
Participants underwent [18F]flutemetamol (amyloid) PET scans after a cranial computed tomography scan for attenuation correction on a Biograph mCT scanner (Siemens Healthcare) at Hospital Clinic, Barcelona. Participants received an intravenous bolus dose of 185 MBq (range 104.25–218.3 MBq, mea...