Novel derivatives of imidazopyridinylbenzeneamines and novel derivatives of benzothiazolylbenzeneamines are disclosed that offer improved behavior when used as imaging agents for positron emission tomography of beta-amyloids. Also disclosed is a palladium-catalyzed reaction scheme under microwave conditions ...
With the advent of new therapeutic strategies aimed at reducing β-amyloid (Aβ) burden in the brain to potentially prevent or delay functional and irreversible cognitive loss, there is increased interest in developing agents that allow assessment of Aβ burden in vivo. Amyloid imaging with PET ...
BETA-AMYLOID PET IMAGING AGENTS 来自 百度文库 喜欢 0 阅读量: 12 申请(专利)号: EP20070797254 申请日期: 2007-04-19 公开/公告号: EP2021340A2 公开/公告日期: 2009-02-11 申请(专利权)人: THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES 发明人...
Cross-sectional and longitudinal analyses over a mean three-year timeframe were performed on the European amyloid-PET imaging AMYPAD-PNHS dataset that phenotypes 1260 individuals, including 1032 CN individuals and 228 participants with questionable functional impairment. Amyloid-PET was assessed continuously...
Another milestone in the radiological diagnostics of amyloid diseases was the discovery by Klunk and colleagues (University of Pittsburgh, US) of the 11C-labeled PET tracer “Pittsburgh compound B” (PiB) to bind selectively to fibrillar Aβ [90]. This made it possible to reveal amyloid ...
Assessment of brain beta-amyloid deposition in transgenic mouse models of Alzheimer’s disease with PET imaging agents 18F-flutemetamol and 18F-florbetabenAssessment of brain beta-amyloid deposition in transgenic mouse models of Alzheimer’s disease with PET imaging agents 18F-flutemetamol and 18F-florbet...
As a biomarker of beta-amyloid, positron emission tomography (PET) amyloid imaging offers a unique opportunity to detect the presence of this protein in the human body during life. Besides Alzheimer's disease (AD), deposits of beta-amyloid in the brain are also present in other ...
Background: Human amyloid PET imaging agents, particularly 18F-labeled agents which allow distribution and potentially widespread use, are rapidly becoming more validated and available. In this context, dedicated instrumentation in support of human PET amyloid imaging has the potential to provide several...
Synthesis and 11C﹍abelling of (E,E)3′,4′ヾihydroxystyryl)3′﹎ethoxy﹉ydroxystyryl) benzene for PET imaging of amyloid deposits Carboxylic acid derivatives of the amyloid-binding dye Congo red do not enter the brain well and are thus unable to serve as in vivo amyloid-imaging agent.....
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