Novel derivatives of imidazopyridinylbenzeneamines and novel derivatives of benzothiazolylbenzeneamines are disclosed that offer improved behavior when used as imaging agents for positron emission tomography of beta-amyloids. Also disclosed is a palladium-catalyzed reaction scheme under microwave conditions ...
Background: Human amyloid PET imaging agents, particularly 18F-labeled agents which allow distribution and potentially widespread use, are rapidly becoming more validated and available. In this context, dedicated instrumentation in support of human PET amyloid imaging has the potential to provide several...
3 D-QSAR of PET Agents for Imaging β-Amyloid in Alzheimer ' s Disease Accumulation of excess senile plaques (尾-amyloid, A尾plaques) in the brain is strongly associated with the pathogenesis of Alzheimer's disease (AD). While... MK Kim,I Choo,H Lee,... 被引量: 0发表: 2007年 Stru...
Two other PET imaging tracers,florbetapir(Amyvid, Eli Lilly and Company) andflutemetamol(Vizamyl, GE Healthcare), were approved previously by the FDA in 2012 and 2013, respectively. As with these other imaging agents, a positive florbetaben scan does not establish a diagnosis of AD or any other...
Amyloid PET imaging: applications beyond Alzheimer's disease. Clin Transl Imaging 2015; 3: 39-55.Catafau AM, Bullich S. Amyloid PET imaging: applications beyond Alzheimer's disease. Clin Transl Imaging 2015; 3:39-55. https://doi.org/10.1007/s40336-014-0098-3 PMID: 25741489...
Macrocyclic Gadolinium-Based Imaging Agents The liposomal composition comprises a macrocyclic Gd-based imaging agent. In some aspects, the macrocyclic gadolinium-based imaging agent comprises Gd(III)-DOTA conjugated to a phospholipid, e.g.: or a salt (e.g., a sodium salt) thereof. In some aspe...
Objective: Brain amyloid imaging using positron emission tomography (PET) is of increasing importance in the premortem evaluation of dementias, particularl... VL Villemagne,CA Mclean,K Reardon,... - 《Journal of Neurology Neurosurgery & Psychiatry》 被引量: 60发表: 2009年 Nutrient intake and br...
BrainHumansBrain InjuriesAniline CompoundsThiazolesFemaleMaleAmyloid beta-PeptidesComment on JAMA Neurol. 2014 Jan;71(1):23-31.doi:10.1038/nrneurol.2013.250Hemi, MalkkiNat Rev NeurolNature Reviews NeurologyMalkki H (2014) Traumatic brain injury: PET imaging detects amyloid deposits after TBI. Nat ...
PET imaging of two different mouse models with Ab pathology clearly visualize Ab in the brain. The PET signal increases with age and correlates closely with brain Ab levels. Thus, we demonstrate that antibody-based PET ligands can be successfully used for brain imaging. 1 Department of Public ...
The invention relates to a precursor for a [ 18 F]-labeled PET tracer for imaging of Alzheimer's Disease, its synthesis and the process for preparing the respective [ 18 F]-labeled PET tracer.doi:WO2011095593 A1SCHMITT-WILLICH, Heribert...