Amyloid light-chain amyloidosis (AL) is characterized by deposits of immunoglobulin 魏 or 位 free light chains (FLCs) produced by clonal bone marrow plasma cells. FLCs transform into amyloid fibrils and accumulate progressively in multiple organs and tissues. The main targets are the heart and ...
Immunoglobulin light chain amyloidosis (AL) is the most common form of systemic amyloidosis, accounting for about 70% of all cases [34]. This disease occurs typically in people with monoclonal gammopathy, a disorder characterized by proliferation of the plasma cell clones. The increased Ig-LC prod...
Systemic light chain (AL) amyloidosis is caused byBlood: The Journal of the American Society of HematologyOliva L, Orfanelli U, Resnati M, et al. The amyloidogenic light chain is a stressor that sensitizes plasma cells to proteasome inhibitor toxicity. Blood. 2017;129(15):2132-2142. https...
Primary amyloid light-chain (AL) amyloidosis is the most frequent type, with nearly 50% of all patients developing cardiac involvement [1]. It has been reported that the median survival of the patients is 6 months from the onset of heart failure (HF) if untreated [2], while patients who...
amyloidosis (redirected fromamyloid disease) Thesaurus Medical Encyclopedia Related to amyloid disease:amyloidosis,Prion diseases am·y·loid·o·sis (ăm′ə-loi-dō′sĭs) n. Any of a group of diseases or conditions characterized by the formation and deposition of amyloid in various organs an...
et al.Clinical value of minimal residual disease assessed by multiparameter flow cytometry in amyloid light chain amyloidosis.J Cancer Res Clin Oncol148, 913–919 (2022). https://doi.org/10.1007/s00432-021-03653-z DOIhttps://doi.org/10.1007/s00432-021-03653-z ...
amyloids. Glenner and his colleagues soon applied the method to the “primary” (today: AL) amyloidosis [48] and found the relationship between this amyloidosis and immunoglobulin light chains. AL amyloidosis is a neoplastic disease and belongs to the clinically most significant amyloid -related ...
Amyloid light-chain (AL) amyloidosis is a systemic disease characterized by the deposition of misfolded immunoglobulin light chain, causing organ failure, and in particular cardiac involvement is a leading cause of morbidity and mortality. We report the case of a 47-year-old man without prior card...
Systemic AA amyloidosis: epidemiology, diagnosis, and management The global incidence of amyloidosis is estimated at five to nine cases per million patient-years. While amyloid light-chain (AL) amyloidosis is more ... RDA Diego,JM Galvan,MT Filigghedu,... - 《Clinical Epidemiology》 被引量:...
Light chain amyloidosis (AL), the most common systemic amyloidosis, is caused by the overproduction and the aggregation of monoclonal immunoglobulin light chains (LC) in target organs. Due to genetic rearrangement and somatic hypermutation, virtually, each AL patient presents a different amyloidogenic ...