淀粉样蛋白-β 前体蛋白就是一个重要的例子。它是一种大膜蛋白,通常在神经生长和修复中起着重要作用。然而,结构的损坏会破坏神经细胞,导致阿尔茨海默病的思想和记忆丧失。 APP结构探秘 β 淀粉样蛋白前体蛋白 (APP) 是一种具有多种功能的复杂蛋白质。它存在于全身细胞的表面。像许多膜栓系蛋白一样,它由由柔性...
The meaning of AMYLOID BETA is beta-amyloid. How to use amyloid beta in a sentence.
beta amyloid 美 英 网络淀粉样蛋白;淀粉样蛋白质 英英 网络释义 n. 1. a protein that accumulates in clumps in the brain as a result of a gene variation, leading to the memory loss and dementia that are features of Alzheimer's syndrome ...
The meaning of BETA-AMYLOID is an amyloid that is derived from a larger precursor protein and is the primary component of plaques characteristic of Alzheimer's disease —called also A-beta, amyloid beta, amyloid beta peptide, amyloid beta protein. How to
取而代之的是,观察到Abeta42和其他低聚物引起阴离子荧光染料的快速细胞泄漏,这表明膜通透性普遍提高。导致的离子和分子通量失调可能为许多淀粉样变性疾病中Ca 2+失调提供了由低聚物介导的毒性的常见机制。离子起着至关重要的作用,因为它们的跨膜浓度梯度很强,并且参与了细胞功能障碍和死亡。 2型糖尿病中的胰岛淀粉...
Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1. Nat. Cell Biol. 2, 463–465 (2000). Article CAS PubMed Google Scholar Takasugi, N. et al. The role of presenilin cofactors in the gamma-secretase complex. Nature 422, 438–441 (...
英文名称:Amyloid beta-peptide(25-35) 产品货号:M06092 产品规格:1mL(10mM)|1mg|5mg|10mg Amyloid beta-peptide(25-35)是阿尔茨海默氏淀粉样蛋白β肽的Aβ(25-35)片段,在培养细胞中显示出神经毒性活性。 注:本品仅可用于科研实验,严禁用于临床医疗及其他用途!
amyloid beta英英释义 noun beta-amyloid In Alzheimer's patients, the amyloid beta protein somehow goes off track and clumps together in sticky plaques that destroy healthy brain tissue.—Nancy McVicar In Alzheimer's, the possible infectious agent under scrutiny is a protein called amyloid-beta best...
推荐:Beta-Amyloid (1-42) Beta amyloid proteins 聚集指南(以下方案仅供参考,请根据您的具体实验需求进行调整): 1. 将Aβ肽(1-42)粉末溶于冷的六氟-2-丙醇(HFIP)。肽溶液在室温下孵化至少1小时,以建立单体化和随机化的结构。(Solid Aβ peptide was dissolved in cold hexafluoro-2-propanol (HFIP). The...
Beta-Amyloid (β-Amyloid)Beta-amyloid is the monomeric or oligomeric soluble or aggregated form (fibrillar or porous) of insoluble Aβ fragments of the amyloid precursor protein (APP). Alzheimer's DiseaseAmyloidSpringer Berlin Heidelbergdoi:10.1007/3-540-29623-9_6297...