Testing causality in the association between amyloid‐β and tau in genetically identical twinsdoi:10.1002/alz.063170Coomans, Emma MTomassen, JoriOssenkoppele, RikKonijnenberg, EllesRikken, Roos M.Collij, Lyduine E.Golla, Sandeep SVWindhorst, Albert D....
As the differential diagnosis of dementias based on established clinical criteria is often difficult, biomarkers for applicable diagnostic testing are curr... M Bibl,B Mollenhauer,H Esselmann,... - 《Brain A Journal of Neurology》 被引量: 435发表: 2006年 CSF tau protein and β-amyloid (1–...
Based on the findings of meta-analysis in the present study, CSF tau and Aβ42 levels in AD and controls may be considered as potential biomarker along with the clinical phenotype to perform them during high quality diagnostic testing in dementia.doi:10.4236/aad.2012.13005Rachna AgarwalNeelam Ch...
SUN CITY COHORT]]>doi:10.1016/j.jalz.2017.07.635Lih-Fen LueMarwan N. SabbaghAndre GuerraDouglas Gordon WalkerKewei ChenEric M. ReimanAlzheimer's & Dementia
Targeting Aβ and tau in Alzheimer's disease, an early interim report. Exp. Neurol. 223, 252–266 (2010). Article CAS PubMed Google Scholar Ness, D. K. et al. Reduced β-amyloid burden, increased C-99 concentrations and evaluation of neuropathology in the brains of PDAPP mice given ...
(Aβ1-40/42are the most common isoforms) and CTFγ. After secretion, Aβ peptides first oligomerize into different soluble species then convert their conformation into profibrils and cross-β-sheet fibrils, forming amyloid plaques. Aβ aggregates interact with tau proteins to exert the toxic ...
Hippocampal volume and memory were assessed across multiple follow-up examinations covering up to 6.8 years. Clustering revealed one group (39%) with more pathological concentrations of all biomarkers, which could further be divided into one group (20%) characterized by tauopathy and high FABP3 ...
Glyocogen synthase kinase 3 (GSK3) plays an important role in the pathophysiology of Alzheimer’s disease (AD) through the phosphorylation of tau. Recent work has suggested that GSK3β also plays a role in the amyloid pathway of AD through genetic interactions with APP and APBB2 on in vivo...
Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by neuropathologic changes involving beta-amyloid (Aβ), tau, neuronal loss, and other associated biological events. While levels of cerebrospinal fluid (CSF) Aβ and tau peptides have enhanced the antemortem detection ...
Last, downstream biomarker evidence (CSF tau proteins and MRI volumetry) that the drug ameliorates neurodegeneration will, together with beneficial clinical effects on cognition and functioning, be essential for labeling an anti-Aβ drug as disease modifying. 展开 ...