GABA uptake inhibition — diazepam — amygdala — kindling — epilepsy — seizuresThe prophylactic effect of an inhibitor of synaptosomal GABA uptake, SK&F 89976-A (N-[4,4-diphenyl-3-butenyl]-nipecotic acid), on the development of amygdala kindled seizures was studied in adult female rats. ...
Amygdala kindling of forebrain seizures and the occurrence of brainstem seizures in genetically epilepsy-prone rats. Epilepsia 1996;37:188-97.Coffey LL, Reith ME, Chen NH, Mishra PK, Jobe PC. Amygdala kindling of forebrain seizures and the occurrence of brainstem seizures in genetically epilepsy-...
The seizures induced by pilocarpine: a novel experimental model of intractable epilepsy. Synapse. 1989, 3: 154-171. 10.1002/syn.890030207. Article CAS PubMed Google Scholar Turski WA, Czuczwar SJ, Kleinrok Z, Turski L: Cholinomimetics produce seizures and brain damage in rats. Experientia....
The piriform cortex in epilepsy: What we learn from the kindling model HemingCheng, ...ZhongChen, inExperimental Neurology, 2020 2.3Kindling-induced transient alterations in the PC As long as the kindling seizures generate and propagate repeatedly, it is unsurprising that the above-mentioned activit...
Kindling of the mammalian limbic system has been suggested as a model of epileptogenesis in complex partial seizure disorder2 (CPS). The most commonly agreed upon problems of an affective nature associated with epilepsy are anxiety and depression2,42,87.
WS Schwark,M Haluska - 《Epilepsy Research》 被引量: 577发表: 1987年 Effects of lamotrigine and levetiracetam on seizure development in a rat amygdala kindling model In kindling models of epilepsy, the period during which repeated stimulation evokes intensifying seizures is attributed to an underlying...
Audiogenic seizures, a model of brainstem epilepsy, are characterized by a tonic phase (sustained muscular contraction fixing the limbs in a flexed or extended position) associated with a short cortical electroencephalogram flattening. When sound-susceptible rats are exposed to repeated acoustic stimulatio...
The temporal-lobe-like seizures produced by local anesthetics (deJong and Walts, 1966) have at least two possibly important contributions to human pathological conditions: 1) they may help explain the mechanisms underlying temporal lobe epilepsy and/or psychosis occasionally associated with this condition...
Sudden unexpected death in epilepsy (SUDEP) is becoming increasingly recognized as a very real and devastating problem in which impaired breathing is thought to play a critical role. Researchers believe breathing may be impaired during and after seizures
The amygdala complex substantially contributes to the generation and propagation of focal seizures in patients suffering from temporal lobe epilepsy (TLE). A cellular substrate for increased excitability in the human amygdala, however, remains to be identified. Here, we analyzed the three-dimensional mo...