(2008) Medium optimization for enhanced production of Rifamycin B by Amycolatopsis mediterranei S699: combining a full factorial design and a statistical approach. Process Biochem 43, 954-960.MA F X,KIM J H,KIM S B,SEO Y G,CHANG Y K,HONG S K,KIM C J.Medium optimization for enhanced ...
(RcaNSAR) andAmycolatopsis mediterraneiS699 (AmedNSAR) [74]. On the other hand, the OSBS/NSAR subfamily also contains OSBS enzymes with no apparent activity with NAAs, such asBacillus subtilisYtfD2orStaphylococcus aureusOSBS [51,73,74]. The same occurs for the recently described OSBS from...
mediterranei S699, U32 probably employs the same two alternatives to cope with rifamycin cytotoxicity, that is, several mutations in RNA polymerase β-subunit (AMED_0656) to lower its affinity for rifamycins and a rifamycin exporter RifP (AMED_0633) to prevent the intracellular accumulation of ...
Detection of tatiomicin from the fermentation of heterologous hostS. coelicolorM1152::tat. Top) Extracted ion chromatogram (EIC) based onm/z = 827.25.S. coelicolorM1152 (purple),S. coelicolorM1152::tat (blue),Amycolatopsissp. DEM30355 (black) and tatiomicin standard (red). Bottom) ...
Ten new proansamycin B congeners (1–10) together with one known (11) were isolated and characterized on the basis of 1D and 2D NMR spectroscopic and HRESIMS data from theAmycolatopsis mediterraneiS699 ΔPM::rifR+rif-orf19mutant. Compounds8and9featured with six-membered ring and five-...
Amexanthomycins A–J, pentangular polyphenols produced by Amycolatopsis mediterranei S699rifAX.ZhuJ.ShenY.APPLIED MICROBIOLOGY AND BIOTECHNOLOGYLi, X.; Wu, X.; Zhu, J.; Shen, Y. Amexanthomycins A-J, pentangular polyphenols produced by Amycolatopsis mediterranei S699∆rifA. Appl. Microbiol....
Amycolatopsis mediterraneiRifamycinRegulationInteractomicsAmycolatopsis mediterranei S699 produces rifamycin B and successors of this strain are in use for the industrial production of rifamycin B. Semisynthetic derivatives of rifamycin B are used against Mycobacterium tuberculosis that causes tuberculosis. Although...
Statistical medium optimization to enhance the production of rifamycin B by Amycolatopsis mediterranei S699ChangJoon Kim
Amycolatopsis mediterranei S699 produces rifamycin B and successors of this strain are in use for the industrial production of rifamycin B. Semisynthetic derivatives of rifamycin B are used against Mycobacterium tuberculosis that causes tuberculosis. Although the rifamycin biosynthetic gene cluster was ...
Genomic modifications for enhanced antibiotic production in rifamycin derivative-producing Amycolatopsis mediterranei S699 strains: focusing on rifQ and rifO genesdoi:10.3389/frabi.2024.1399139Müller, MoritzBialas, ElenaSturm, IrinaSood, UtkarshLal, Rup...