Several symptoms may occur at the same or different threshold level of medication, and evaluation of these toxic effects may reveal data suggesting the possible mode of action of the drug. In addition, these data may be useful in equating symptoms observed in suspected cases of drug contamination...
THE coccidiostat amprolium [l-(4-amino - 2 - n - propyl - 5 - pyrimidinyl-methyl)-2-picolinium chloride. HCl] has a mode of action involving thiamine metabolism (Rogers et al., 1960). Incorporation of excessive amounts of the drug in poultry rations produced a thiamine deficiency in ...
A new RP-HPLC method was developed and validated for the simultaneous determination of amprolium hydrochloride and sulfaquinoxaline sodium in a powder dosage form. The chromatographic separation was achieved by isocratic mode with Phosphate buffer and Acetonitrile (30:70; v/v), as mobile phase and...