分类号:R563.1+单位代码:10183研究生学号:01673010密级:公开吉林大学硕士学位论文(学术学位)麦冬皂苷D通过激活AMPK/NF-κB信号通路缓解PM.5诱导的肺泡上皮细胞炎症反应OphiopogoninDattenuatesPM.5-inducedinflammationviaactivatingAMPK/NF-κBsignalingpathwayinmic
研究成果发表在The Journal of Cellular and Molecular Medicine期刊题为“Local delivery of simvastatin maintains tooth anchorage during mechanical tooth moving via anti-inflammation property and AMPK/MAPK/NF-kB inhibition”。 通过应用体外张力系统加载外部机械刺激,将PDLCs用 10% 等双轴应变以 0.1Hz 拉伸24小...
辛伐他汀局部给药在机械性牙齿移动过程中发挥重要作用，通过其独特的抗炎特性和调控AMPK/MAPK/NF-kB途径，增强牙齿在生物力学诱导下的锚定。牙颌面畸形的正畸治疗通过OTM调整牙齿排列，生物力学适应是关键。研究者探索了生物疗法如辛伐他汀的潜力，它作为一种降胆固醇药物，已在临床试验中显示对牙周炎的治...
In addition to increasing the activities of p-AMPK alpha, B-LAP elevated NAD(+)/NADH ratios in the kidneys and decreased the renal levels of nuclear p-NF-kappa B and its correspondent downstream effectors TNF-alpha, IL-1 beta, IL-6, and iNOS in the kidneys. Also, B-LAP effectively ...
炎症反应是由多种因素引起的,AMPK/SIRT1/NF-κB信号通路是与能量代谢密切相关的一条信号通路,它介导的炎症反应受到机体能量代谢改变的影响.其中AMPK是能量代谢的感受器,它会激活下游分子SIRT1, SIRT1的激活会抑制NF-κB的活性,进而影响炎症反应的发生发展.在衰老的过程中,机体的炎症状态加剧,而有规律的长期运动(...
In conclusion, SYB protected brain I/R injury through reducing expression of inflammatory cytokines and this effect might be partly due to the inhibition of NF-κB mediated by AMPK. 1. Introduction Around the world, ischemia stroke had been the third leading cause of death and the leading ...
目的:通过观察温和灸对动脉粥样硬化家兔血清脂蛋白胆固醇变化,病理组织形态,超微结构变化的干预效应,从AMPK-SIRT1-NFκB信号通路角度探讨温和灸干预动脉粥样硬化的可能作用机制.方法:新西兰纯种健康雄性家兔68只按编号随机分为两组:空白组(12只)和造模组(56只),造模组用高脂饲料喂养与免疫损伤方法进行造模,模型制备成功...
In addition to increasing the activities of p-AMPKα, B-LAP elevated NAD+/NADH ratios in the kidneys and decreased the renal levels of nuclear p-NF-κB and its correspondent downstream effectors TNF-α, IL-1β, IL-6, and iNOS in the kidneys. Also, B-LAP effectively ameliorated renal ...
Western blotting was used to determine the expression of TGF-1, SIRT1, PGC-1a and HO-1 and the phosphorylation levels of p38, ERK1/2, JNK, AMPK and NF-kB p65 in lung tissue. Hemin significantly reduced lung indices, increased terminal body weight. It als...
to observe autophagosomes in Eca109 cells and WB assay was applied to detect the protein expressions of microtubule-associated protein 1 light chain 3 (LC3)-II/LC3-I, Beclin-1, B-lymphoma-2 (Bcl2), Bcl2-associated X protein (BAX), p-AMPK, SIRT...