信号通路(AMPK、MAPK、NF-κB、PI3K-AKT、mTOR、TGF-β谁有白大褂编辑于 2024年06月30日 03:09 若是单纯AMPK信号通路减少就不能说明是因为磷酸化激活而减少。信号通路中很多磷酸化是激活状态,也有部分是去磷酸化激活的。想要证明信号通路的分子激活,就要去证明总的AMPK/mTOR通路没有变化。以此为对照来说明AMPK...
AMPK 是一种代谢调节因子，它通过调节细胞内的代谢过程（如糖代谢）来维护细胞的代谢平衡。AMPK 被激活当细胞内能量存储（如葡萄糖）不足时，它能够调节代谢过程并促进能量生产。MAPK 是一种细胞外信号通路，它通过从细胞外的刺激（如生长因子）诱导的细胞内信号传导，对细胞增殖、生长、分化、凋亡等生物...
接下来,为了进一步阐明AMPK在张力条件下对SMV刺激的PDLCs的影响,实验通过Western blot检测了MAPK/NF-κB信号(图2 A)。结果显示,0.05UM SMV处理下调了p-ERK、p-P38和p-P65的折叠表达(图2 B),但这种变化会被Compound C 改变,并进一步被AICAR恢复,这与p-AMPK水平呈负相关。然后通过ELISA检测了处理的上清液中TNF-...
这篇文章是JAK激酶抑制剂挽救肠道稳态失衡。
Ferroptosis occurs with the development of oxidative stress and energy stress [6], and the activity of cancer-related signaling pathways can regulate these two stress responses. The dysregulation of the mitogen-activated protein kinase (MAPK) and AMP-activated protein kinase (AMPK) pathways, which ...
MAPK与AMPK 实验狗 15年毕业于中科院上海320大院某所,现在正好十年了。每年所里大约招25-30人(直博)。截至目前我同级,高一级,低两级的同学各去世一人。 对了我今年38。走的同学、师兄弟们大概35左右吧,一个博士期间,两个毕业三五年内。R.I.P.…
We determined different dietary on expression of AMPK and MAPK signaling response in soleus muscle after a bout endurance swimming exercise. Total 160 Sprague-Dawley rats were divided into two groups by two dietary condition: (SCHO, n=40) and high fat diet(HFAT, n=120). High fat dietary we...
最近的研究表明,AMPK 信号还可以通过磷酸化其关键成分 RAF/KSR 家族激酶来可逆地调节癌细胞中过度活跃的 MAPK 信号,这不仅影响致癌作用,还影响针对 MAPK 信号的靶向癌症治疗的结果。在这篇综述中,我们将总结 MAPK-AMPK 信号在癌症生物学中如何相互作用的最新进展,及其对 MAPK 抑制和 AMPK 调节剂的临床癌症治疗的...
In this review, we will summarize the current proceedings of how MAPK-AMPK signalings interplay with each other in cancer biology, as well as its implications in clinic cancer treatment with MAPK inhibition and AMPK modulators, and discuss the exploitation of combinatory therapies targeting both ...
Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independ... The induction of apoptosis in cancer cells is a therapeutic strategy for the treatment of cancer. In the present study, we investigated th...