AMPK调控PGC1α可能包括几种间接机制,如p38MAPK127,HDAC524,128和SIRT1129,所以,AMPK与PGC1α的作用是一系列机制的共同作用结果(图3)。 此外,在有些情况下,AMPK促进转录因子EB(TFEB,下文讨论)的激活,并且TFEB已被证明直接结合激活编码PGC1α基因PPARGC1A的启动子131。除PGC1α,AMPK已经被证实在KRAS驱动的结...
肌肉中PGC1α过表达足以将IIb型(糖酵解)纤维转化为II型和I型线粒体纤维,建立以PGC1α为主调节器的线粒体合成122。PGC1α由几种后转化机制调控,如乙酰化作用123、甲基化作用124和各种激酶的磷酸化作用,包括AKT125和p38 MAPK通路126。有趣的是,有报道显示几种与氧...
肌肉中PGC1α过表达足以将IIb型(糖酵解)纤维转化为II型和I型线粒体纤维,建立以PGC1α为主调节器的线粒体合成122。PGC1α由几种后转化机制调控,如乙酰化作用123、甲基化作用124和各种激酶的磷酸化作用,包括AKT125和p38 MAPK通路126。有趣的是,有报道显示几种与氧化代谢相关的基因在活化时需要PGC1α的表达17,...
(C)VEGF的折叠表达。(D)TNF-ɑ的折叠表达。(E)NF-κB的折叠表达。(F)AMPK的折叠表达。 接下来,为了进一步阐明AMPK在张力条件下对SMV刺激的PDLCs的影响,实验通过Western blot检测了MAPK/NF-κB信号(图2 A)。结果显示,0.05UM SMV处理下调了p-ERK、p-P38和p-P65的折叠表达(图2 B),但这种变化会被Compound ...
·446· J Clin Transfus Lab Med,August.2021,Vol 23,No.4 ·论著· AMPK信号通路在小鼠急性肾损伤发生中的作用 毛艳 卢丽 肖辉 刘潇 【摘要】 目的 探讨磷酸腺苷激活蛋白酶(adenosine phosphate activating protease,AMPK)信号通路在小鼠急性肾损 伤发生中的作用.方法 SPF级BALB/c雄性小鼠(48只)随机分为两组...
SignalingIL-6 PathwayInsulin PathwayJAK/STAT SignalingJNK SignalingmTOR SignalingNeurotrophin PathwayNFKB PathwayNOTCH SignalingP53 SignalingRAS Receptor PathwayTGF-beta PathwayToll-like Receptor PathwayVEGF SignalingWnt SignalingAMPK PathwayATM PathwayBDNF PathwayeNOS PathwayEGF PathwayMAPK PathwayP38-MAPK Pathway...
p38 MAPK110. Quite recently, Leick, and colleagues have reported that an AMPK/PGC-1α-dependent mechanism is likely responsible for exercise-induced VEGF expression in skeletal muscle as well as exercise-training-induced prevention of senescent decline in VEGF protein content111. Intriguingly, AICAR...
AMPK信号通路是一种燃料传感器和调节器,促进各种组织中ATP的产生并抑制ATP的消耗途径。AMPK是一种异三聚体复合物,由催化α亚单位和调节β和γ亚单位组成。该激酶在应对耗尽细胞ATP供应的应激时被激活,如低血糖、缺氧、缺血和热休克。AMP与γ亚单位的结合变构激活复合物,使其成为其主要上游AMPK激酶LKB1的更具吸引力...
Microbial imidazole propionate affects responses to metformin through p38γ-dependent inhibitory AMPK phosphorylation. Cell Metab. 32, 643–653.e4 (2020). Article CAS PubMed PubMed Central Google Scholar Donohoe, D. R. et al. The microbiome and butyrate regulate energy metabolism and autophagy ...
(eIF4E)-binding protein 1; P53, tumor suppressor protein; GLUT4, glucose transporter type 4; ULK1, unc-51 like autophagy activating kinase 1; HIF-1α, hypoxia-inducible transcription factor-1α; VEGF, vascular endothelial growth factor; ACC, acetyl-CoA carboxylase; EMT, epithelial-mesenchymal ...