Cell Rep. 32, 108092 (2020). Article CAS PubMed PubMed Central Google Scholar Monternier, P. A. et al. Beneficial effects of the direct AMP-kinase activator PXL770 in in vitro and in vivo models of X-linked adrenoleukodystrophy. J. Pharmacol. Exp. Ther. 382, 208–222 (2022). ...
Some of these discrepancies may be attributable to off-target effects of the AMPK activator AICAR and the AMPK inhibitor Compound C for AMPK. There are published examples of AMPK-independent roles for both of these compounds (63, 64), stressing the importance of using genetic models to corrobora...
Although metformin is an effective activator of AMPK (Herzig and Shaw, 2018), Yang et al. (Yang et al., 2019b) reported that it can activate AMPK and autophagy by inhibiting mitochondrial complex I and the NLRP3/Caspase-1 pathway through mTOR, thereby alleviating pyroptosis in DCM. It is...
^Gomez-Verjan, Juan Carlos. Clinical Genetics and Genomics of Aging. Springer Nature, 2020. ^Mizushima, Noboru. "Autophagy: process and function." Genes & development 21.22 (2007): 2861-2873. ^Grace, SR Smitha, Girish Chandran, and Jyoti Bala Chauhan. "Terpenoids: an activator of “fuel-s...
In fact, we observed poor p-AMPK attenuation using Compound C, and it has conflicting roles as either an activator or inhibitor of autophagy [35]. Thus, use of this agent alone poses a limitation for analysis of AMPK regulation of autophagy in our system. To address this, we present new...
Terpenoids: An Activator of “Fuel-Sensing Enzyme AMPK” with Special Emphasis on Antidiabetic Activity. Plant and Human Health, Volume 2 pp 227-244. 10 O'Neill H M . AMPK and Exercise: Glucose Uptake and Insulin Sensitivity[J]. Diabetes, Metabolism Journal, 2013, 37(1). 11 O'Neill HM...
However, treatment with the AMPK activator partially alleviated those effects. Our data indicate that Ciprofloxacin may accelerate AngII-induced VSMC senescence through modulating AMPK/ROS signaling and, subsequently, hasten the progression of AAD.
(Gli-1), the central transcription factor that regulates cell proliferation and differentiation in the Hedgehog pathway, particularly in medulloblastoma [47]. The LKB1, also called serine/threonine kinase 11 (STK11), is a known activator of AMPK, is tumor suppressor that act via the inhibition ...
an effect mirrored by the indirect AMPK activator metformin. Other β1-AMPK-specific direct activators MT63-7836and the indole acid derivative PF-0640957737have shown promise as treatments for either prostate cancer or diabetic neuropathy, respectively. Although not investigated, Ser108 phosphorylation is...
Bone marrow mesenchymal stem cells (BMSCs) have been used as important cell-based tools for clinical applications. Oxidative stress-induced apoptosis causes a low survival rate after transplantation, and the underlying mechanisms remain unknown. The endoplasmic reticulum (ER) and mitochondria are vital...