描述:Amphotericin B 是针对多种真菌病原体的多烯抗真菌 (fungal) 剂。Amphotericin B 与麦角甾醇不可逆地结合,导致膜完整性被破坏并最终导致细胞死亡。 CAS:1397-89-3 分子式:C47H73NO17 分子量:924.08 储存条件:固体粉末:-20℃ 3年;溶液:-80℃ 2年、-20℃ 1年 靶点:Fungal;Antib
Amphotericin B is a polyeneantifungalagent against a wide variety offungalpathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. IC50& Target Leishmania Plasmodium 体外研究 (In Vitro) ...
Amphotericin B irreversibly binds to ergosterol and disrupts the integrity of cell membranes, resulting in antifungal activity. 体外活性 方法:人正常结肠上皮细胞 CCD 841 CoTr 和人结直肠癌细胞 HT-29 用含 Amphotericin B (0.05-25 µg/mL) 处理 24 h,使用 Neutral Red method 检测细胞活力。结果:较...
Amphotericin(1397-89-3) B is a polyene macrolide antibiotic which was introduced into clinical medicine in 1955. It is primarily used for the treatment of serious systemic fungal infections. It is also used as an alternative drug for the treatment of drug resistant Leishmania. Amphotericin B is...
Amphotericin B (AmB) is a lifesaving antibiotic used to treat deep-seated mycotic infections. Both the pharmaceutical activity and highly toxic side effects of the drug rely on its interaction with biomembranes, which is governed by the molecular organization of AmB. In the present work we ...
The meaning of AMPHOTERICIN B is an antibiotic that is obtained from a soil streptomycete (Streptomyces nodosus) and is administered typically by intravenous injection chiefly to treat serious, potentially life-threatening, systemic fungal infections.
Systemic antifungal therapy AMPHOTERICIN B Amphotericin B, a polyene antibiotic, acts by binding to ergosterol in the fungal cell membrane, disrupting membrane stability and quickly causing cell death. Because of its efficacy against a broad spectrum of yeast and filamentous fungal pathogens, amphoterici...
别名:两性霉素B 分子式:C47H73NO17 分子量:924.08 纯度:>98% 溶解度:≥ 46.2mg/mL in DMSO 储存:4°C, protect from light 库存:现货 Background Amphotericin B, a polyene antifungal antibiotic, has been produced from a strain of Streptomyces nodosus with an IC50 of 0.028–0.290 μg/ml. ...
两性霉素 B 来源于链霉菌 Amphotericin B from Streptomyces sp. 别名: Fungizone 经验分子式(希尔表示法) C47H73NO17 分子量 924.08 Biochem/physiol Actions Amphotericin B is a polyene antifungal antibiotic from Streptomyces. It has an affinity for sterols, primarily ergosterols, of fungal cell membr...
MCE 国际站:Amphotericin B 产品活性:Amphotericin B是针对多种真菌病原体的多烯抗真菌 (fungal)剂。 它与麦角甾醇不可逆地结合,导致膜完整性破坏并最终导致细胞死亡。 研究领域:Anti-infection 作用靶点:Fungal | Antibiotic | Bacterial | Parasite In Vitro: Amphotericin B administration is limited by infusion-...