Small amphipathic molecules modu- late secondary structure and amyloid fibril-forming kinetics of Alzheimer disease peptide Abeta (1-42). J BiolChem2012; 287 (20): 16947-16954.Ryan TM, Friedhuber A, Lind M, Howlett GJ, Masters C, Roberts BR (2012) Small amphipathic molecules modulate ...
Polymeric nanocarriers are extensively explored as vehicles for encapsulation and delivery of bioactive compounds and therapeutic molecules1,2,3. Synthetic peptides have emerged in recent years as building blocks for polymeric nanocarrier fabrication because of their well-defined and fine-tuned properties4,...
Cell penetrating peptides: efficient vectors for delivery of nanoparticles, nanocarriers, therapeutic and diagnostic molecules. Efficient delivery of therapeutic and diagnostic molecules to the cells and tissues is a difficult challenge. The cellular membrane is very effective in it... SM Farkhani,A Va...
We demonstrate in the current work that small cationic antimicrobial β2,2-amino acid derivatives (Mw < 500 Da) are highly potent againstChlamydia pneumoniaeat clinical relevant concentrations (< 5 μM, i.e. < 3.4 μg/mL).C.pneumoniaeis an atypical respiratory pathogen associated with frequent...
45 While antibodies and other small molecules may activate the TpoR in cell lines, our data would suggest that careful studies will be necessary to establish exactly which biologic function of the TpoR would be induced by these agonistic molecules. The biologic activity would be dependent on the...
If we consider that 10% of Plin4 molecules used in the experiment (=1 nmol) are coating the oil, this gives a total Plin4 helical area of 3.6 × 1016 nm2, in the same range as the estimated oil surface area (Fig. 6i; see Supplementary Note 1 for details)....
Analysis was carried out on 122 participants (tered actions are really simple to provide and cheap. The self-administered ALSFRS-R had been found to be psychometrically sound and certainly will be used as an instrument to monitor condition progression and function in ALS.3D publishing, also calle...
We have previously shown that Vpr-(52–96) delivers high numbers of DNA molecules into the cells (29). However, the mechanism by which the delivery is done is unknown. To evaluate this process, we used electron microscopy. At early times (i.e. after 2 h; Fig. 3) the Vpr-(52–96...
Here we should also note that during the expansion of the WT model the tight association of the lipid molecules with the N-terminal helix is conserved (Fig. 2c–e). While these lipids are 'dragged' away from protruding into the structure (Fig. 1c–e), their interactions with the ...
Complex—Two molecules are combined, to form a complex through a process called complexation or complex formation, if the are in contact with one another through noncovalent interactions such as electrostatic interactions, hydrogen bonding interactions, and hydrophobic interactions. Modification—...