神外前沿讯,近日,来自德国海德堡大学医院的研究团队在国际顶刊CELL杂志(影响因子31.30)上报道应用狂犬病病毒逆行追踪,发现了胶质母细胞瘤中的神经元-肿瘤互作网络,揭示了肿瘤通过突触整合快速融入脑神经回路,促进了其侵袭性生长。(参考阅读...
短时阵雨 体感温度30° 大风东北偏东8公里/小时 湿度92% 紫外线指数0(最大值11) 云量83% 降雨量0.39毫米 19:00 25° 19% 多云 体感温度29° 大风东北偏东6公里/小时 湿度95% 紫外线指数0(最大值11) 云量85% 降雨量0毫米 20:00 25° 16% ...
加入2-(2-(4-乙酰基-3-(三氟甲 基)-1H-吡唑-l-基)乙酰胺基)-4, 5, 6, 7-四氢苯并[b]噻吩-3-甲酰胺 (50 mg, 0.121 mmol)和氰基硼氢化钠(7. 58 mg, 0.121 ,1),接着 用微波辐射将反应加热至IOO 。C30分钟。用水淬灭反应混合物,接着 通过制备反相HPLC纯化。用乙酸将产物馏分酸化至pH 3,...
2013;33(16):6990–7002. Article PubMed PubMed Central CAS Google Scholar Li N, Lee B, Liu RJ, Banasr M, Dwyer JM, Iwata M, et al. mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science. 2010;329(5994):959–64. Article PubMed PubMed...
α-氨基-3-羟基-5-甲基-4-异噁唑丙酸(AMPA)受体是离子型谷氨酸受体的一种亚型,分布于中枢神经系统的突触后膜,介导大多数快速兴奋性神经传递.CX717是由美国Cortex制药公司研制的苯甲酰胺类AMPA受体正向调节剂,能够降低AMPA受体失活或降敏的速度从而提高突触的活性,与阿尔茨海默病、...
18, 23–33 (2003). Article PubMed Google Scholar Wright, A. & Vissel, B. The essential role of AMPA receptor GluR2 subunit RNA editing in the normal and diseased brain. Front. Mol. Neurosci. 5, 34 (2012). CAS PubMed PubMed Central Google Scholar Isaac, J. T., Ashby, M. & ...
S4a,b). We next tested whether genetically expressing AMPAR i-mAbs (from transfected plasmids and AAVs) interfered with AMPAR function. We used an antibody heavy chain-Halo from an anti-GluA1 antibody33 (N355/1), which does not bind GluA1 on its own, as a control for overexpression of...
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1a) and, ChR2-EYFP expressing axon terminals were observed in the anterior part of the BLA, consistent with previous studies32,33 (Fig. 1b). We then conducted whole-cell recordings in BLA pyramidal neurons in acute brain slices obtained from the mice. In the BLA, ChR2 expressing axons ...
Y. Yang, X.B. Wang, M. Frerking, Q. Zhou Delivery of AMPA receptors to perisynaptic sites precedes the full expression of long-term potentiation Proc Natl Acad Sci USA, 105 (2008), pp. 11388-11393 CrossrefView in ScopusGoogle Scholar [33] J.P. Johansen, C.K. Cain, L.E. Ostroff...