Available data from postmarketing reports and a small study with amlodipine use in pregnant women with mild-to-moderate chronic hypertension did not identify a drug-associated risk for major birth defects, miscarriage, or adverse maternal or fetal outcomes There are risks to the mother and fetus a...
The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the U.S. general population, the estimated background risk of major birth defects and miscarri...
MajorHighly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. ModerateModerately clinically significant. Usually avoid combinations; use it only under special circumstances. MinorMinimally clinically significant. Minimize risk; assess risk and consider an alter...
Gingival hyperplasia is one of the side effects commonly caused by three major groups of drugs such as a) anticonvulsants b) antihypertensives 鈥 calcium channel blockers c) immunosuppressants. Previously among antihypertensives Nifedipine induced enlargements were commonly reported in literature with ...
Atorvastatin has not been studied in conditions where the majorllipoprotein abnormality is elevation of chylomicrons (FredricksonTypes I and V). Dosage for Caduet CADUET Dosage of CADUET must be individualized on the basis of both effectiveness and tolerance for each individual component in the treatm...
MajorHighly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. ModerateModerately clinically significant. Usually avoid combinations; use it only under special circumstances. MinorMinimally clinically significant. Minimize risk; assess risk and consider an alternative...
The metabolites of amlodipine have been charac- terised in animals and in human subjects.1 Metabolism of am- lodipine is complex and extensive, and in common with other dihydropyridines oxidation to the pyridine analogue represents a major step. About 5% of a dose was recovered from urine as ...
The major specific advantages ofamlodipine(Norvasc; Istin in the United Kingdom) are (1) the slow onset of action and the long duration of activity (seeTable 3-5) and (2) the vast experience with this drug in hypertension. It was the first of the longer-acting “second-generation”CCBs...
The compound is not classified as a carcinogen by major health agencies, but like all medications, it should be used with caution. Prolonged or incorrect use can lead to hypotension (low blood pressure), causing symptoms such as fainting, dizziness, and shock. In rare cases, it may cause ...
Atorvastatin has not been studied in conditions where the majorllipoprotein abnormality is elevation of chylomicrons (FredricksonTypes I and V). Dosage for Caduet CADUET Dosage of CADUET must be individualized on the basis of both effectiveness and tolerance for each individual component in the treatm...