teratogenicity or other embryo/fetal toxicity was found when pregnant rats and rabbits were treated orally with amlodipine maleate at doses up to 10 mg amlodipine/kg/day (approximately 10 and 20 times the MRHD based on body surface area, respectively) during their respective periods of major ...
Gingival hyperplasia is one of the side effects commonly caused by three major groups of drugs such as a) anticonvulsants b) antihypertensives 鈥 calcium channel blockers c) immunosuppressants. Previously among antihypertensives Nifedipine induced enlargements were commonly reported in literature with ...
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. Minor Minimally clinically significant. Minimize risk; assess risk and consider an altern...
The metabolites of amlodipine have been charac- terised in animals and in human subjects.1 Metabolism of am- lodipine is complex and extensive, and in common with other dihydropyridines oxidation to the pyridine analogue represents a major step. About 5% of a dose was recovered from urine as ...
The compound is not classified as a carcinogen by major health agencies, but like all medications, it should be used with caution. Prolonged or incorrect use can lead to hypotension (low blood pressure), causing symptoms such as fainting, dizziness, and shock. In rare cases, it may cause ...
[1]. Besides efficacy, occurrence of adverse effects (AEs) plays an important role in maintaining adherence with medications [2]. Occurrence of peripheral edema is the major reason for poor adherence with amlodipine. The Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-B...
There are no available data on use in pregnant women to inform a drug-associated risk for major birth defects and miscarriage; however, there are published studies with each individual component of the drug combination Data from observational studies regarding potential embryofetal risks for NSAID use...
The major specific advantages ofamlodipine(Norvasc; Istin in the United Kingdom) are (1) the slow onset of action and the long duration of activity (seeTable 3-5) and (2) the vast experience with this drug in hypertension. It was the first of the longer-acting “second-generation”CCBs...
The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the U.S. general population, the estimated background risk of major birth defects and miscarri...
MajorHighly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. ModerateModerately clinically significant. Usually avoid combinations; use it only under special circumstances. MinorMinimally clinically significant. Minimize risk; assess risk and consider an alternative...