Context Outcomes and determinants of response in AML with rearrangements of the Mixed Lineage Leukemia (MLL) gene are unknown. Objectives To determine the mutational, phenotypic, and clinical characteristics of MLLr AML. Design A retrospective analysis including adult patients with newly diagnosed MLLr ...
Pigneux A, Labopin M, Maertens J et al (2015) Outcome of allogeneic hematopoietic stem-cell transplantation for adult patients with AML and 11q23/MLL rearrangement (MLL-r AML). Leukemia 29(12):2375–2381 Article CAS PubMed Google Scholar Pirker R, Wallner J, Geissler K et al (1991)...
The patients had a KMT2A(MLL)-rearrangement and a TP53 mutation with a PICALM-AF10 fusion, respectively. The third patient treated at the 100-mg dose level had SETD2 and RUNX1 comutations and achieved a complete remission with confirmed negative minimal residual disease after 2 cycles of ...
Hb 9.9 g/dL and platelets 14 × 109/L. BM evaluation performed at another Institution was diagnostic of AML with 46,XY,t(9;22)(q34;q11)[9]/47,idem,+8[7]/46,XY[4]; aBCR-ABL1rearrangement (p210 fusion) (Fig.5A) andNPM1mutation type B were detected (Fig.5B), whilst...
Frequent co-expression of HoxA9 and Meis 1 genes in infant acute lymphoblastic leukaemia with MLL rearrangement. Br J Haematol 2002; 119: 119–121. Article CAS Google Scholar Moskow JJ, Bullrich F, Huebner K, Daar IO, Buchberg AM . Meis 1, a PBX1-related homeobox gene involved in ...
Relevance of presenting white blood cell count and kinetics of molecular remission in the prognosis of acute myeloid leukemia with CBFbeta/MYH11 rearrangement. Haematologica 2000; 85: 699–703. CAS Google Scholar Lester WA, Hull DR, Fegan CD, Morris TC . Respiratory failure during induction ...
In the pediatric patient population, the presence of a KMT2A rearrangement in ALL, as well as AML, is associated with refractory disease and the need to go to a potentially curative transplant. Many different patient populations could benefit [from this therapy]. We have been struggling to ...
Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c) 2022, Blood Cancer Journal Show abstract Targeting FLT3 Mutation in Acute Myeloid Leukemia: Current Strategies and Future Directions 2023, Cancers Venetoclax resistance: Mechanistic insights and future...
An Infant With Congenital Leukemia Cutis and AML-M5 With MLL Gene Rearrangement. A bone marrow biopsy specimen demonstrated acute myelogenous leukemia (M4 subtype). Following consultation with pediatric oncology and the recognition of the ... Turan,Bayhan,Kismet,... - 《Journal of Pediatric Hematolo...
“F”. VAF variant allelic frequency (mean), CMCBFB::MYH11, PRPML::RARA, biC biallelicCEBPA, NOS not otherwise specified, MR(C) myelodysplasia-related (changes),MECOM-rMECOMrearrangement, T mutatedTP53, L low VAF (0–14%), M medium VAF (15–29%); Remaining cases showedSF3B1VAFs ≥...