[11] Chen N, Pan J, Zhou Y, et al. Gilteritinib-based combination therapy in adult relapsed/refractory FLT3-mutated acute myeloid leukaemia. Br J Haematol. Published online November 8, 2023. doi:10.1111/bjh.19182 [1...
近日,《Cancer Discovery》杂志上发表了题为“A novel type of monocytic leukemia stem cell revealed by the clinical use of venetoclax-based therapy”的论文,该研究发现了一类新型单核性白血病干细胞,并揭秘其介导AML患者经维奈克拉治...
[7] Xiaohui Hu, et al. Maintenance Therapy with Chidamide Plus Azacitidine after Allogeneic Hematopoietic Stem Cell Transplantation for High-Risk Acute Myeloid Leukemia Patients. 2023 ASH. 4991. [8] Juan Xu, et al. Myeloablative Fractionated Busulfan Conditioning Regimen with Chidamide in Patients wi...
AMLrisk stratificationindividualized therapypersonalized therapychemotherapyradiotherapyalkylating agentstopoisomerase II inhibitorsTherapy-related acute myeloid leukemia (t-AML) comprises 10–20% of all newly diagnosed cases of AML and is related to previous use of chemotherapy or ionizing radiother...
Journal of Cancer Research and Clinical Oncology (2023) 149:13811–13821 https://doi.org/10.1007/s00432-023-05115-0 RESEARCH AML consolidation therapy: timing matters Adrian‑Manuel Reimann1 · Enrico Schalk2 · Felix Jost1,6 · Dimitrios Mougiakakos2 · Daniela Weber3...
4. Perna, F., Berman, S.H., Soni, R.K., Mansilla-Soto, J., Eyquem, J., Hamieh, M., Hendrickson, R.C., Brennan, C.W., and Sadelain, M. (2017). Integrating Proteomics and Transcriptomics for Systematic Combinatorial Chimeric Antigen Receptor Therapy of AML.Cancer Cell32, 506–519...
4. Pei S, Pollyea DA, Gustafson A, et al. Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid LeukemiaMonocytic AML Is Resistant to Venetoclax. Cancer Discov. 2020;10(4):536-551.5. Sharon D, Cathelin S, Mirali S, et al. Inhibition of ...
Current acute myeloid leukemia (AML) therapy is inadequate for the great majority of patients. Major challenges are peculiar to the elderly and the infirm. There is no prospect of further advances using current standard agents. At our current state of knowledge, all potential classes of agents me...
[3] Kennedy B E, et al. NAD+salvage pathway in cancer metabolism and therapy[J]. Pharmacologicalresearch,2016,114:274-283. [4] Liran I S ,Amanda M,Lawrence H, et al.Tracing the origins of relapse in acute myeloid leukaemia to stem cells[J].Nature: International weekly journal of scien...
近日,南方医科大学南方医院血液内科刘启发教授、宣丽教授团队在《信号转导与靶向治疗》(Signal Transduction and Targeted Therapy,STTT)杂志刊发题为“Impact of genetic patterns on sorafenib efficacy in patients with FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation: a ...