[4]DUPLOYEZ N, WILLEKENS C, MARCEAU-RENAUT A, et al. 2015. Prognosis and monitoring of core-binding factor acute myeloid leukemia: current and emerging factors. Expert Rev Hematol [J], 8: 43-56. [5]DOHNER H, ESTEY E, GRIMWADE ...
AML伴NPM1主要有两组免疫表型,一组是幼稚髓系的免疫表型谱,另一组是单核系免疫表型谱(CD36+,CD64+,CD14+)。 CD34 is negative in most cases but CD34+ cases do occur and have been associated with an adverse prognosis. A very small fraction ...
HCT is never indicated in patients in CR1, except for the small fraction of patients with per- sistent RQ-PCR positivity of PML-RARA after consolidation (<1%), given the poor prognosis associated with this subset. HCT is also indicated in APL patients who relapse and achieve second or ...
The role of MDR-related proteins in the prognosis of adult acute myeloid leukaemia (AML) with normal karyotype. Hematol Oncol. 2007;25(1):38-43.The role of MDR-related proteins in the prognosis of adult acute myeloid leukaemia (AML) with normal karyotype. Damiani Daniela,Tiribelli Mario,...
Prognosis of acute myeloid leukemia (AML) patients depends on patient-related features, disease manifestations at the time of presentation, and intrinsic disease-related genetic features, such as cytogenetic abnormalities and driver mutations. Prognostic
innovative immunomodulatory agents, all aimed at striking a delicate balance between averting GvHD and safeguarding the beneficial graft-versus-leukemia (GvL) effects (Malard et al.2023; Choi et al.2010; Cooke et al.2017). Splenomegaly is associated with a poor prognosis and primary graft failure...
TP53 mutation has been associated with a poor prognosis in both AML and MDS [58, 59]. A recent study analyzed 3,324 patients with MDS for TP53 mutations and allelic imbalances, and delineated two subsets of patients with distinct phenotypes and outcomes. One-third of TP53-mutated patients ...
Acute myeloid leukemia (AML) is a heterogeneous disease with poor prognosis and treatment options. A new study reveals a unique inflammatory signature in pediatric and adult AML malignant cells that is associated with the infiltration of atypical B cells in the bone marrow microenvironment, which ...
Additionally, the fairly good sensitivity, specificity, and clinical relevance of miR-182 promoter methylation discovered in our study make it a valuable tool for identifying and monitoring methylation changes associated with prognosis. Therefore, we offer a rapid and quantitative method to predict the ...
AML with t(8;21)(q22;q22.1) is usually associated with a high rate of complete remission and long―term disease―free survival when treated with intensive consolidation therapy (e.g. high―dose cytarabine). So...