Fig.3. In vivo efficacy of BIF002 in the luciferase-expressing AML PDX Model 4.Long-term Effects on LSCs: In a separate patient-derived xenograft (PDX) model focused on LSCs, second transplanted mice from T cells and...
We derived PDX model LEXFAM 2799 (NPM1 wt; FLT3 wt, t(8;21)) and LEXFAM 2966 (NPM1 mut; FLT3 wt) from treatment nave patients and established in immunocompromised NSG mice. LEXFAM 2799 is a fast-growing model with passaging times of 33 days, whereas LEXFAM 2966 displays a pass...
PDX#1 is derived from a patient with KMT2A-rearranged r/r AML and has been reported as highly aggressive AML model that only partially responded to targeted therapy.71,72,73 In mice engrafted with PDX#1, ADCLEC.syn1 induced durable remissions and outperformed a reference CD33-CAR-28z1XX....
We then investigated the chemoresistant potential of each tumor population based on the presence of known chemoresistance-related gene expression signatures. Four transcription signatures were identified to be associated with chemoresistance in PDX models, including LSC activity, active OXPHOS, LRC, and se...
NM-B33-TG01 品系描述 人急性骨髓性白血病细胞 品系状态 成瘤性验证完成 *使用本品系发表的文献需注明: OCI-AML-3-Luc cell line (Cat. NO. NM-B33-TG01) was purchased from Shanghai Model Organisms Center, Inc.. 验证数据 Figure 1. Luciferase activity assay of OCI-AML-3-Luc cell line Figur...
The combination therapy reduced the percentage of circulating hCD45+ cells compared with both vehicle control and single-agent venetoclax in both PDX models and versus single-agent RMC-4550 in the PDX #1 model (Figures 6B and S6C). After 28 days of treatment or at the pre-determined humane...
NM-B33-TG01 品系描述 人急性骨髓性白血病细胞 品系状态 成瘤性验证完成 *使用本品系发表的文献需注明: OCI-AML-3-Luc cell line (Cat. NO. NM-B33-TG01) was purchased from Shanghai Model Organisms Center, Inc.. 验证数据 Figure 1. Luciferase activity assay of OCI-AML-3-Luc cell line Figur...
Interestingly, active oxidative phosphorylation, but not quiescent dormancy, was recently shown to be a dominant feature in cytarabine-treated AML cells in PDX mouse models [6]. The lack of molecular profiles of LSCs in these mice may be due to the following reasons that may not be mutually ...
Gedatolisib increases survival of mice in a sorafenib-resistant PDX model. (a) Colony-forming units assay from sorafenib-resistant primary AML cells treated with either 1 or 10 nM sorafenib in combination with 50 nM gedatolisib. Results represent the average of triplicate assays. Error bars ...
NM-B33 品系描述 人急性骨髓性白血病细胞 品系状态 成瘤性验证中 *使用本品系发表的文献需注明: OCI-AML-3 cell line (Cat. NO. NM-B33) was purchased from Shanghai Model Organisms Center, Inc.. 验证数据 野生型细胞株不进行出售服务,仅作为荷瘤鼠和体内药效进行服务相关...