We report a 78-year-old male who, 3 years after treatment for acute monocytic leukaemia, developed t-MDS (refractory anaemia with excess blasts-2) that was initially suspected to be a relapse. Cytogenetic analysis of the initial AML had revealed +8 and del(16). These abnormalities ...
Arrows indicate COX IV+ cells (AML blasts) present within the central BM as well as spreading to other regions. Scale bar: 200 µm (upper panels), 50 µm (bottom panels). Legend: BM (bone marrow), B (bone) and M (muscle). Created with BioRender.com. B Tumor burden in ...
MDS and AML originate during CH from clonal hematopoiesis of indeterminate potential (CHIP) or clonal cytopenia of undetermined significance (CCUS), which falls into the category of clonal cytopenia (Fig.1a). CCUS can be distinguished from CHIP thanks to the advancements in NGS techniques. It repr...
Acute myeloid leukemia (AML) is caused by altered maturation and differentiation of myeloid blasts, as well as transcriptional/epigenetic alterations, all leading to excessive proliferation of malignant blood cells in the bone marrow. Tumor heterogeneity due to the acquisition of new somatic alterations ...
Acute myeloid leukemia (AML) is caused by altered maturation and differentiation of myeloid blasts, as well as transcriptional/epigenetic alterations, all leading to excessive proliferation of malignant blood cells in the bone marrow. Tumor heterogeneity due to the acquisition of new somatic alterations...
Updated results from the multicenter Phase 1b/2 trial demonstrated that APR-246 + AZA is a well-tolerated combination with high response rates in HMA-treatment naïve TP53 mutated higher risk MDS, MDS/MPN, and oligoblastic AML (20%-30% blasts) patients (NCT03072043). Patients enrolled...
(q22; q22) usually correlated with distinct morphological features including large size blasts with Auer rods, numerous azurophilic granules and large pseudo Chediak-Higashi granules as well as homogeneous pink colored cytoplasm[3]. Bone marrow showed ...
Leveraging previous studies describing the pharmacokinetics properties of entinostat29, we also demonstrated that EVI1 protein levels markedly decrease in circulating AML blasts following 4 mg/m2of entinostat compared to ara-C both in treated patients (Fig.4G) or in the matched 3q26 PDLX models ...
5 Definitive proof that a small population of leukemic stem cells produce the AML blasts comes from 6-week primary and secondary engraftment experiments in NOD/SCID mice.6 Further studies have revealed that these SCID-leukemia initiating cells (SL-ICs) share many properties with normal HSCs, ...
方法选取2010年6月至2011年6月在山东大学附属省立医院血液科就诊的住院或门诊患者85例,包括AA组25例;MDS组48例,其中难治性贫血(refractoryanemia,RA)组22例,难治性贫血伴原始细胞增多(refractoryanemiawithexcessblasts,RAEB)组26例;AML组12例,另选取正常对照8例(均为非血液病患者),采用流式细胞仪(flowcytometry...