There is a major unmet medical need for treatment options in elderly patients with acute myeloid leukemia (AML) who are deemed ineligible for intensive treatment. The recent approval of decitabine in the European Union for the treatment of patients with AML≥65years old highlights the potential ...
Median overall survival (OS) was longer in patients achieving RBC-TI X8 weeks (4.3 vs 2.0 years in non-responders; Po0.0001) or cytogenetic response (4.9 vs 3.1 years in non-responders; P ¼ 0.010). Time to acute myeloid leukemia (AML) progression was longer in patients achieving RBC-...
Quantitative DNA methylation predicts survival in adult acute myeloid leukemia. Blood 2009; 115: 636–642. Article Google Scholar Figueroa ME, Skrabanek L, Li Y, Jiemjit A, Fandy TE, Paietta E et al. MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation. ...
[2]Shen YY,Zhang TT,Zhang LN,et al. Allogeneic stem cell transplantation can prolong the survival of patients with NUP98-rearranged acute myeloid leukemia.Bone Marrow Transplant . 2023 Jul 7. doi: 10.1038/s41409-023-02030-3 [3] Swerdlow SH, Campo E, Harris NL. et al. World Health Or...
理论上讲,Hubbell的疫苗技术可以击溃一切肿瘤,真正实现"一物降万病魔"的宏愿。参考文献：Slezak, A. J., et al. (2024). Cysteine-binding adjuvant enhances survival and promotes immune function in a murine model of acute myeloid leukemia. Blood Advances. doi.org/10.1182/bloodadvances.2023012529.
Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults, with a dismal 5-year survival rate of only 24%. This prognosis is even worse in refractory or relapsed (R/R) patients, where the 5-year survival rate falls below 10% [1]. Given these bleak statistics,...
4 While CAR T-cell therapy is an established treatment option in B-cell malignancies, it is still in its incipient stages for AML treatment.5 If successful, HEMO-CAR-T could provide a new treatment pathway for patients with AML, which has a 5-year survival rate of less than 30% in ...
Investigates the relevance of in vitro leukemia cell survival to the overall survival of patients with acute myeloid leukemia (AML) using MTT-assay. Absence of correlation of leukemia cell survival and Bcl-2 expression; Association of growth factor withdrawal with rapid onset of cellular apoptosis.被...
Acute myeloid leukemia in the elderly: assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy. A Southwest Oncology Group study. Blood 1997; 89: 3323–3329. CAS PubMed Google Scholar Miyazaki Y, Kuriyama ...
通过对部分家系口腔黏膜样本的联合基因序列分析,证实部分DDX11突变为胚系突变(图3),这对白血病患者精准诊疗及全球应用最广泛的半相合干细胞移植实施“北京方案”中优选供者,以提高患者生存期,具有重要的意义。该研究结果于2023.11.22在线发表于Leukemia(Q1)。