acute myeloid leukemiahealthcare resource utilizationcostrelapseContext AML is the most common form of acute leukemia in adults. The age-adjusted incidence of AML in the USA is 4.3/100,000 people, with median age of 68 years at diagnosis. Following diagnosis, treatment options include intensive ...
Aumann1, Justine M. Jones1, G. Willemijn Veldhuijzen1, Branden S. Moriarity1,3,4 & David A. Largaespada1,3,4,5 Acute myeloid leukemia (AML) can display de novo or acquired resistance to cytosine arabinoside (Ara-C), a primary component of induction chemotherapy....
Moreover, blood and tissue infiltration with leukemia cells were strongly reduced by the inhibitor (Figure S6E). Notably, the BM cKitHiCD11bLow leukemic progenitor cells were almost completely eliminated by the inhibitor (Figure 7D). To pinpoint the molecular basis of the leukemia inhibitory ...
acute myeloid leukemiaresource utilizationhospitalizationHEORHealthcare resource utilization and costs of managing AML patients are substantial, with hospitalization being the main cost driver of AML care. In the Phase 3 QUAZAR AML-001 maintenance trial, lower rates and durations of hospitalization with ...
The study was supported by Bristol Myers Squibb.doi:10.1016/S2152-2650(20)30715-1Ashley TabahDavid HuggarBrenna L. BradyKrutika Jariwala-ParikhKrystal HueyRonda M. CopherThomas W. LeblancClinical Lymphoma Myeloma and Leukemia
Azacitidine (AZA) versus conventional care regimens (CCR) in older patients with newly diagnosed acute myeloid leukemia (>30% bone marrow blasts) with morphologic dysplastic changes: A subgroup analysis of the AZA-AML-001 trial. Blood 2014, 124, 10. [Google Scholar] Seymour, J.F.; Döhner...
This assumption was based on the significant improvement of overall survival (OS) obtained in the AZA-MDS-001 trial [7] and the Cancer and Leukemia Group B (CALGB) protocols, in which 32% [8] and 38% [9,10] of the trial population had AML with 20%–30% BM blasts, respectively. ...
Keywords: alternative splicing; acute myeloid leukemia; FLT3-ITD; NPM1; FAB; maturation state Cancers 2021, 13, 3929. https://doi.org/10.3390/cancers13163929 https://www.mdpi.com/journal/cancers Cancers 2021, 13, 3929 2 of 17 1. Introduction Whole genome profiling efforts in the last ...