Leukemic cells are eradicated by various cell death ways such as immunogenic cell death (ICD), autophagic cell death, ferroptosis and cuproptosis. Generally, traditional radiotherapy and chemotherapy induces ICD. It promotes an antitumor immune response through tumor-specific antigenicity and adjuvanticity...
(A) Schematics of the CD33-CAR containing a CD33-targeting single-chain variable fragment (scFv), a CD8 transmembrane domain (TM), 4-1BB and CD33ζ intracellular domains (ICD), and of the dNPM1-TCR containing dNPM1-specific variable alpha and beta chains (Vα and Vβ) as well as the...
Notably, the BM cKitHiCD11bLow leukemic progenitor cells were almost completely eliminated by the inhibitor (Figure 7D). To pinpoint the molecular basis of the leukemia inhibitory effect in the Tet2−/−;Flt3ITD mouse model, we tested the ex vivo signaling and killing effect of A51, A86...
Importantly, we found that there appears to be no universal splicing profile associated with concomitant FLT3-ITD and NPM1 mutations that would transcend all subtypes of AML cells. Instead, we find that the co-occurrence of these two aberrations is associated with differential splicing of FAB ...