We therefore conducted the first large-scale GWAS to identify risk alleles for adult de novo AML.Methods: Whole-genome genotyping was performed on two independent American case-control sets, using Illumina Infinium Omni-1 Quad-bead arrays. GWAS quality control measures consisted of excluding samples...
据统计,约5%~10%的aml病例与遗传变异导致的易感性相关。 2、近年来,研究者们基于全基因组关联分析(genome-wide association studies,简称gwas)已经鉴定出超过94个与aml患病风险、治疗反应或预后相关的snp位点。这些aml易感snp位点能够通过与靶标基因的相互作用来调控基因表达,进而影响疾病的发生,诊断及aml病人的预后。
We collected data samples from the Gene Expression Omnibus (GEO) database and extracted pQTL data from genome-wide association studies (GWAS) to identify overlapping genes between the DEGs and GWAS data. Gene enrichment and pathway annotation analyses were performed on these genes. Furthermore, we...
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