Using flow cytometry, we have investigated the effects of 0.5μ M all- trans –retinoic acid (ATRA) on bcl-2 expression in the blast cells of 25 acute myeloblastic leukemia (AML) patients and the HL-60 cell line after incubation for 6 days. We observed a significant decrease of bcl-2 ...
1B). MCL-1 was suppressed in both the OCI-AML3 and THP-1 cells but the drug had little effect on BCL2 expression (Fig. 1C). The ability of GCS-100 to potently suppress AKT and ERK phosphorylation is consistent with inhibition of galectin-mediated RAS signaling by the agent though ...
B-cell leukemia/lymphoma-2 (BCL2) is an antiapoptotic protein that promotes leukemic cell survival through regulation of the mitochondrial apoptotic pathway. An increased level of BCL-2 expression relative to the pro-apoptotic BAX protein is associated with poor outcome in patients receiving intensive...
BCL-2 protects cells against apoptosis. BCL-2 expression in AML has been associated with decreased sensitivity to cytotoxic chemotherapy and a higher rate of relapse [3]. Venetoclax is an orally bioavailable selective inhibitor of BCL-2, promoting intrinsic apoptotic pathway activation resulting in ...
Non-mutated TP53 and elevatedexpression of its regulator Hdm2 is another interesting feature of AML. Studies haveshown that the p53 pathway can be linked to Flt3 signaling as a subset of FLT3-ITDpatients expresses increased levels of the anti-apoptotic protein Bcl-2 and hyperphosphorylatedp53 ...
RNA-seq technology has enabled researchers to study intricate biological processes by mapping and quantifying transcripts in disease states (Fadl et al.2020). However, traditional bulk RNA-seq only provides the average gene expression per tissue or cell culture, which hides the variability between ind...
RNA-seq technology has enabled researchers to study intricate biological processes by mapping and quantifying transcripts in disease states (Fadl et al.2020). However, traditional bulk RNA-seq only provides the average gene expression per tissue or cell culture, which hides the variability between ind...
PTPN13 expression was lower in clear cell renal cell carcinoma (ccRCC) patients and cell line predicting a shorter survival time. The upregulation of PTPN13 repressed the proliferation, colony formation and invasion, while enhanced the apoptosis of ccRCC cells[45]. The AUC values for the risk ...
BCL2 Inhibitor (ABT-737): A Restorer of Prednisolone Sensitivity in Early T-Cell Precursor-Acute Lymphoblastic Leukemia with High MEF2C Expression? Early T-cell precursor-acute lymphoblastic leukemia (ETP-ALL) has been identified as a high-risk subtype of pediatric T-cell acute lymphoblastic leukem...
Fadraciclib alters cell cycle regulatory gene expression to induce apoptosis OCI-AML3, MOLM-13 and MV4–11 were treated with 0.75, 0.5, and 1 µM of fadraciclib, respectively, for 4 and 24 h and the effect on cell cycle regulatory gene expression investigated. The heatmap depicts ...