近日,《Cancer Discovery》杂志上发表了题为“A novel type of monocytic leukemia stem cell revealed by the clinical use of venetoclax-based therapy”的论文,该研究发现了一类新型单核性白血病干细胞,并揭秘其介导AML患者经维奈克拉治...
急性髓性白血病(acute myeloid leukemia, AML)是一种侵袭性血液系统恶性肿瘤,尽管作为一线治疗的高强度化疗可使多达 70% 的患者获得缓解,但持续存在的白血病干细胞(leukemic stem cells, LSC)使得疾病复发时常发生【1】。因此,根除LSC的新疗法可能会改善临床结局,而关键之一是识别LSC中存在的漏洞。先前的研究表明,...
近日,广东医科大学附属湛江中心医院临床医学研究所陈璋辉课题组、广东医科大学附属湛江中心人民医院血液内科杨志刚课题组联合浙江大学医学院高向伟课题组在Cancer Research期刊发表了最新研究成果The RNA m6A reader YTHDF1 is required for acute...
Epitope base editing of CD45 in hematopoietic cells enables universal blood cancer immune therapy. Sci Transl Med 15, eadi1145. 10.1126/scitranslmed.adi1145.Marone, R., Landmann, E., Devaux, A., Lepore, R., Seyres, D., Zuin, J., Burgold, T., Engdahl, C., Capoferri, G., Dell'...
Patient-Derived Cancer Stem Cells Offer Diagnostic and Therapeutic Potential in Brain Cancer Antibody-Drug Conjugate Under Study in Platinum-Resistant Ovarian Cancer Combos Mark Next Step in Melanoma Immunotherapy Focus on Cancer Prevention Would Moderate Spiraling Costs of CareNewsletter...
For two decades, leukaemia stem cells (LSCs) in chronic myeloid leukaemia (CML) and acute myeloid leukaemia (AML) have been advanced paradigms for the cancer stem cell field. In CML, the acquisition of the fusion tyrosine kinase BCR–ABL1 in a haematopoi
Cancer stem cellsAcute myeloid leukaemia, a known transcription factor, promotes cell proliferation in a variety of cancer cells. Here we show thatis required for survival, quiescence and self-renewal of MLL-AF9 (MA9)-transformed leukemia stem cells (LSCs) in vivo. Mechanistically,upregulation ...
[2] Heo SK,Noh EK,Ju LJ,et al.CD45 dimCD34+CD38-CD133+cells have the potential as leukemic stem cells in acute myeloid leukemia[J].BMC Cancer,2020,20(1):285.[3] Ka ndeel EZ,El Sha rk aw y N,Ha naf i M,et al.Tr a ci ng Leukemia Stem Cells and Their Influence on ...
作为揭示AML中细胞层次结构的第一步,作者重新分析了12名诊断为AML的13653个细胞scRNA-seq,重点关注原始干细胞和祖细胞群(白血病干细胞和祖细胞(leukemia stem and progenitor cells,LSPCs))。作者先前确定了两种正常人类造血干细胞转录组群体:一种是转录组多样性低的深度静止群体,另一种是CDK6表达较高的较浅静止状态...
其研究结果,以“Nuclear NAD+homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells”为题,发表在期刊《Science Advances》上,IF:14.136。 研究背景 急性髓系白血病(AML)代表了异质性髓系恶性肿瘤,结局较差,靶向治疗很少,其中白血病干细胞(LSCs)主要负责复发和治疗抵抗,研究发现,LSCs...