Furthermore, AMLnet outperformed junior human experts and was comparable to senior experts on the test dataset at the patient level. Finally, we provided an interactive demo website to visualize the saliency maps and the results of AMLnet for aiding pathologists’ diagnosis. Collectively, AMLnet ...
Acute myeloid leukemia (AML) is a rapidly-progressing heterogeneous hematologic malignancy characterized by infiltration of the bone marrow, blood, and other tissues by myeloblasts or progranulocytes that fail to undergo normal differentiation [1, 2]. Over the past decade, advances in next-generation...
- 《Blood》 被引量: 87发表: 2011年 Predictors of Early Death in Childhood Acute Promyelocytic Leukemia: Results of an International Retrospective Study Background: Acute promyelocytic leukemia (APL) is a rare subtype of childhood acute myeloid leukemia (AML). Bleeding complications occur in 80% ...
A 21-day dosing schedule was permitted for pts who experienced AML relapse with 5-15% blasts in blood or bone marrow while on-study. Tx could continue indefinitely until the presence of >15% blasts, unacceptable toxicity, or HSCT. The primary endpoint was OS. Secondary endpoints included ...
(n = 764; AML, NOSn = 372, AML-MRC-MLDn = 70, AML-MRC-Cn = 322, Fig.1A) did not differ from the cohort AML, NOS and AML-MRC regarding age, sex, bone marrow blasts, and blood counts (Supplementary Table2A, B). Other gene mutation results were evaluated if ...
Due to its presence in easily accessible fluids, such as saliva, blood and mucus, SLPI has been widely investigated as a potential diagnostic and prognostic biomarker for cancer23. SLPI is expressed by a variety of cells, including granulocytes, monocytes/macrophages, and epithelial cells, and ...
Results Antigen distribution and density inform AML target selection To rationally select AML targets and an adapted targeting strategy for CAR therapy of AML, we quantitatively profiled surface target protein expression in bone marrow and peripheral blood (PB) samples of AML patients and healthy donor...
Firstly, KMT2A and KAT6A have been shown to interact and jointly regulate HOXA gene expression in human cord blood cells during normal early hematopoiesis [14]. Secondly, KAT6Ar AML and KMT2Ar AML exhibit similar gene expression profiles [60, 61], and KAT6A is now recognized as a genetic...
granulocytic leukemia,myelocytic leukemia- a malignant neoplasm of blood-forming tissues; marked by proliferation of myelocytes and their presence in the blood Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc. ...
Blood 142, 771 (2023). Article Google Scholar Budde, L. E. et al. Abstract PR14: CD123CAR displays clinical activity in relapsed/refractory (r/r) acute myeloid leukemia (AML) and blastic plasmacytoid dendritic cell neoplasm (BPDCN): safety and efficacy results from a phase 1 study. ...