A patient started on oral (PO) amiodarone approximately 1 week ago (400 mg/day). The patient is now taking nothing by mouth (NPO), and the physician would like to switch to intravenous (IV) amiodarone. The only information that I could find about PO to IV conversion involved patients who...
Alternatively, one could envision an analogous stereochemical interaction between the prodrug and a target completely unrelated to carboxylesterases or NTP conversion, yet to be characterized, that might underlie the adverse cardiac DDI. Results Stereochemical specificy of interaction between hepatitis C ...