Despite their use for over 50 years, the mechanism of action of this class of drugs remains uncertain, although a number of possibilities are discussed in this review. It seems likely that the aminosalicylates are important free radical scavengers, can reduce leukotriene production and can inhibit...
The exact mechanism is still unknown. However, their action is thought to be predominately topical at the site of inflammation within the colonic mucosa. For most patients with IBD, 5-ASAs must be taken orally. However, if the pure 5-ASA is taken by mouth, it is completely absorbed into ...
Despite their use for over 50 years, the mechanism... SM Greenfield,NA Punchard,JP Teare,... - 《Alimentary Pharmacology & Therapeutics》 被引量: 389发表: 1993年 Review article: the mode of action of the aminosalicylates in inflammatory bowel disease. Sulphasalazine and other 5-aminosalicylic...
Despite their use for over 50 years, the mechanism of action of this class of drugs remains uncertain, although a number of possibilities are discussed in this review. It seems likely that the aminosalicylates are important free radical scavengers, can reduce leukotriene production and can inhibit...
As HO-1 can produce endogenous anti-oxidant and anti-inflammatory moieties such as bilirubin and carbon monoxide (CO), these findings suggest a novel mechanism of action for aminosalicylates, acting as anti-colitic agents through the up-regulation of HO-1 enzyme expression and activity.Brendan J...
As HO-1 can produce endogenous anti-oxidant and anti-inflammatory moieties such as bilirubin and carbon monoxide (CO), these findings suggest a novel mechanism of action for aminosalicylates, acting as anti-colitic agents through the up-regulation of HO-1 enzyme expression and activity.doi:...
Here the chemical structure and pharmacokinetics, mechanism of action, formulations, efficacy, and safety of sulfasalazine and 5-ASA will be reviewed. The roles of rectal and oral delivery, dose response, and optimal duration of therapy will be discussed. Finally, the potential of 5-ASA in ...
Here the chemical structure and pharmacokinetics, mechanism of action, formulations, efficacy, and safety of sulfasalazine and 5-ASA will be reviewed. The roles of rectal and oral delivery, dose response, and optimal duration of therapy will be discussed. Finally, the potential of 5-ASA in ...