Despite their use for over 50 years, the mechanism of action of this class of drugs remains uncertain, although a number of possibilities are discussed in this review. It seems likely that the aminosalicylates are important free radical scavengers, can reduce leukotriene production and can inhibit...
Despite their use for over 50 years, the mechanism... SM Greenfield,NA Punchard,JP Teare,... - 《Alimentary Pharmacology & Therapeutics》 被引量: 387发表: 1993年 Review article: the mode of action of the aminosalicylates in inflammatory bowel disease. Sulphasalazine and other 5-aminosalicylic...
Despite their use for over 50 years, the mechanism of action of this class of drugs remains uncertain, although a number of possibilities are discussed in this review. It seems likely that the aminosalicylates are important free radical scavengers, can reduce leukotriene production and can inhibit...
From our results we suggest that (1) the extra- (scavenger) and intracellular inhibition of superoxide radicals by 5-aminosalicylic acid may be an important mechanism of action, (2) an intact aminophenolic structure may be necessary for such actions, and (3) the inability of inflammatory ...
Here the chemical structure and pharmacokinetics, mechanism of action, formulations, efficacy, and safety of sulfasalazine and 5-ASA will be reviewed. The roles of rectal and oral delivery, dose response, and optimal duration of therapy will be discussed. Finally, the potential of 5-ASA in ...
Here the chemical structure and pharmacokinetics, mechanism of action, formulations, efficacy, and safety of sulfasalazine and 5-ASA will be reviewed. The roles of rectal and oral delivery, dose response, and optimal duration of therapy will be discussed. Finally, the potential of 5-ASA in ...
As HO-1 can produce endogenous anti-oxidant and anti-inflammatory moieties such as bilirubin and carbon monoxide (CO), these findings suggest a novel mechanism of action for aminosalicylates, acting as anti-colitic agents through the up-regulation of HO-1 enzyme expression and activity.Brendan J...
Conclusions: This in vivo study favours the existence of an interaction between azathioprine and aminosalicylates through a mechanism which remains unclear. This drug–drug interaction should be taken into account when using azathioprine and aminosalicylates simultaneously....
Cytokines and mechanisms of action of glu- cocorticoids and aminosalicylates in the treatment of ulcerative colitis and Crohn's disease. Aliment Pharmacol Ther. 1996;10 Suppl 2:93-98.Zimmerman MJ, Jewell DP. Cytokines and mechanism of ac- tion of glucocorticoids and aminosalicylates in the ...