This class of antibiotics presentssignificant challenges for residue analysis. Unlike most other antibiotic classes, these compounds are not amenable to extraction from tissue or milk usingacetonitrile or other organic solvents. In this study, the aminoglycosides areextracted from meat tissue or milk ...
Aminoglycosidesare small, hydrophilic, and constitute one of the oldest classes of antibiotics.Streptomycinwas the first aminoglycoside discovered, in 1914, and represents just one of a large class of antibiotics that share in common the general structure of two or more amino-sugars joined by a gly...
The structure ofaminoglycoside antibioticsmainly consists of an aminocyclic alcohol and multipleaminosugarmolecules, which are bonded byglycosidic bonds. Commonaminoglycoside antibioticsmainly includestreptomycin, baloneycin, andamikacin. This class of antibiotics blocks microbial protein synthesis mainly by i...
With the discovery of the biosynthetic pathways of various antibiotics pointing out the role of each gene/protein in their antibiotic-producing strains, it became apparent that the biosynthetic gene clusters can be manipulated to produce modified antibiotics. This new approach is known as the ...
Aminoglycoside phosphotransferases (APHs) catalyze the ATP-dependent phosphorylation of these antibiotics. Two particular enzymes in this class, APH(3\u27)-IIIa and AAC(6\u27)-APH(2\u22), are produced in gram-positive cocci and have been shown to phosphorylate aminoglycosides on their 3\u27 ...
C. The β-lactam antibiotics prevent toxic effects of the aminoglycoside antibiotics. D. The combination decreases incidence of superinfections. E. The combination decreases the doses of the two class antibiotics. 相关知识点: 试题来源: 解析 B null ...
8820/18 www.nature.com/ja REVIEW ARTICLE Destination of aminoglycoside antibiotics in the 'post-antibiotic era' Yoshiaki Takahashi and Masayuki Igarashi Aminoglycoside antibiotics (AGAs) were developed at the dawn of the antibiotics era and have significantly aided in the treatment of infectious ...
Aminoglycosides were first discovered as a natural product class of antibiotics in the 1940s (Becker and Cooper2013), starting with Waksman, Schatz, and Bugie isolating streptomycin fromStreptomyces griseusin 1944 (Schatz et al.1944). Streptomycin was the first antibiotic treatment for tuberculosis (...
Certain strains of Staphylococcus epidermidis resistant to the aminoglycoside antibiotics were shown to contain an enzyme that inactivates the kanamycins, ... Partha,Santanam,Fritz,... - 《Journal of Infectious Diseases》 被引量: 10发表: 1976年 Purification and properties of two gentamicin-modifying...
Aminoglycoside antibiotics constitute an important class of clinically useful drugs which are imperiled by the emergence of resistant organisms. Aminoglycoside resistance in the clinics is primarily due to the presence of modifying enzymes which N-acetylate, O-adenylate or O-phosphorylate the antibiotics....