aminoalkylmethacrylate copolymer EYM466oral anticoagulantintestinal absorptionexcipientspassive diffusion/transportsolubilityThe aim of this study was to find out polymeric compounds that can inhibit the interaction between YM466, a novel anticoagulant, and bile to improve its oral bioavailability. In vitro ...
Disclosed is a pharmaceutical composition containing an aminoalkylmethacrylate copolymer E, an aminoalkylmethacrylate copolymer E uniformly blended with an acidic substance, and a poorly water-soluble drug. This pharmaceutical composition enables to maintain solubility of the poorly water-soluble drug for at...
A soft contact lens which comprises a water-swollen gel of a polymer prepared by polymerizing one or more hydrophilic monomers such as 2- hydroxyethyl methacrylate, one or more cross-linking monomers, a monomer that contains metal-chelat... DG Vanderlaan,SB Orr - US 被引量: 43发表: 1998...
Evaluation of aminoalkylmethacrylate nanoparticles as colloidal drug carrier systems. Part I: synthesis of monomers, dependence of the physical properties ... N-trimethylaminoethylmethacrylate (TMAEMC) nanoparticles with quaternary ammonium groups located at their surfaces, possessed a nearly constant ...
bioavailabilityaminoalkylmethacrylate copolymer EYM466oral anticoagulantintestinal absorptionexcipientspassive diffusion/transportsolubilitydoi:info:doi/10.1002/jps.23484Takemura, ShigeoKondo, HiromuWatanabe, ShunsukeSako, KazuhiroOgawara, Ken‐ichiHigaki, Kazutaka...
UMEJIMA, HIROYUKIKURIMOTO, IPPEIYOSHIDA, TAKATSUNEYOSHIHARA, KEIICHIYoshida T, Yoshihara K, Umejima H, Kurimoto I (2008) Aminoalkyl methacrylate copolymer E for maintaining solubility of poorly water-soluble drug. PCT Int Appl Patent WO 2008081829...
This invention is based on the addition of the amino alkyl methacrylate copolymer E which is denaturalized chemically, you display the transmissivity of the medicine formulation, and the strategy in order to improve dissolved in this case as for this chemical denaturation, there is containing 4 ...
Yoshida, T.; Kurimoto, I.; Umejima, H.; Watanabe, S.; Sako, K.; Kikuchi, A. Effects of dissolved state of aminoalkyl methacrylate copolymer E/HCl on solubility enhancement effect for poorly water-soluble drugs. Colloid Polym. Sci. 2013, 291, 1191-1199....
The present invention relates to a strategy for improving the permeability and solubility of pharmaceuticals, based on adding a chemically modified amino alkyl methacrylate copolymer E, wherein the chemical modification is the quarternization of a fraction of the existing amino alkyl groups.LANGGUTH, ...
Quaternization of the aminoalkyl methacrylate additive copolymer and to improve the permeability and solubility of pharmaceuticals The present invention relates to a strategy for improving the permeability and solubility of pharmaceuticals based on the addition of an aminoalkyl methacrylate copolymer and ...