The aminoacyl-tRNA synthetase enzyme requires Mg2+ and is highly specific both for the amino acid and for the tRNA. Each synthetase exists for each amino acid, and this synthetase functions for all the different tRNA molecules for that amino acid. Eukaryotic cells and some bacteria have 20 ...
Aminoacyl tRNA synthetase An aminoacyl tRNA synthetase (aaRS) is an enzyme that catalyzes the esterification of a specific amino acid or its precursor
M. Structure of tyrosyl-tRNA synthetase refined at 2.3 A resolution. Interaction of the enzyme with the tyrosyl adenylate intermediate. J. Mol. Biol. 208, 83–98 (1989). CAS PubMed Google Scholar Schmidt, E. & Schimmel, P. Residues in a class I tRNA synthetase which determine ...
tRNA- RNA molecules present in the cell (in at least 20 varieties, each variety capable of combining with a specific amino acid) that attach the correct amino acid to the protein chain that is being synthesized at the ribosome of the cell (according to directions coded in the mRNA) ...
Structure of pyrrolysyl-tRNA synthetase, an archaeal enzyme for genetic code innovation Pyrrolysine (Pyl), the 22nd natural amino acid and genetically encoded by UAG, becomes attached to its cognate tRNA by pyrrolysyl-tRNA synthetase (PylRS). ... JM Kavran,S Gundllapalli,P O'Donoghue,......
This chapter focuses on aminoacyl-tRNA synthetase autoantibodies. The first non-Jo-1 antisynthetases (aS) was anti-PL-7 that was found to react with threonyl-tRNA synthetase (ThrRS). A remarkable feature of the aS is that antibodies to different members of the same enzyme family in ...
This is primarily achieved by the direct attachment of an amino acid to the corresponding tRNA by an aminoacyl-tRNA synthetase, although intrinsic proofreading and extrinsic editing are also essential in several cases. Recent studies of aminoacyl-tRNA synthesis, mainly prompted by the advent of ...
As a whole the present data indicate that the suppression by mt aa-RS is probably not related to the enzyme activities per se, and may be due to a stabilizing chaperon-like effect of the synthetase molecules on the tRNA structure altered by the mutations. 展开 ...
Aminoacyl-tRNA synthetases (AaRSs) are ubiquitously expressed enzymes that ensure accurate translation of the genetic information into functional proteins... J Ognjenovi?,M Simonovi? - 《Rna Biology》 被引量: 9发表: 2017年 Synthetase polyspecificity as a tool to modulate protein function The site...
Transfer RNA dynamics contribute to cancer development through regulation of codon-specific messenger RNA translation. Specific aminoacyl-tRNA synthetases can either promote or suppress tumourigenesis. Here we show that valine aminoacyl-tRNA synthetase (