The effect of pH on the properties of the partial reactions of arginyl-tRNA synthetase of E. coli has been investigated. V max of pyrophosphorolysis of arginyl adenylate has a pH optimum at pH 6.1, whereas V max of the transfer of arginine to tRNA has a pH optimum of 8.2. These ...
MCE 国际站:Aminoacyl-tRNA Synthetase 靶点描述:氨酰-tRNA 合成酶 (AARS) 是通过在蛋白质翻译的第一步中将氨基酸共价连接到其同源 tRNA 来催化氨酰化反应的酶。在哺乳动物中,AARS 通常以游离形式或以多 tRNA 合成酶复合物(MSC)的形式存在,后者由 8 个 AARS 和 3 个非酶促 AARS 相互作用的多功能蛋白(AIMP1...
tyrosyl-tRNA synthetase (TyrRS), lysyl-tRNA synthetase (LysRS) and alanyl-tRNA synthetase (AlaRS) have been shown to be associated with Charcot-Marie-Tooth (CMT) disease, one of the most common inherited neurological disorders6,7,8,9. However, how these...
The final parasite discussed below in the context of tRNA synthetase targets is the helminth parasite Brugia. Brugia malayi is a nematode spread between humans by mosquitoes and is one of several parasites to cause human filariasis. Lymphatic filariasis is caused by immunological reaction to the ad...
英文: Evolutionary Diversities of Aminoacyl-tRNA Synthetases中文: 氨酰-tRNA合成酶的进化差异 英文: Research Progress on Aminoacyl-tRNA Synthetases中文: 氨酰-tRNA合成酶的研究进展 英文: Translational Fidelity Mechanism of Aminoacyl-tRNA Synthetases中文: 氨酰-tRNA合成酶维持翻译忠实性的机制 ...
For this purpose, aminoacyl tRNA synthetases are being pursued as targets for new drugs. These enzymes are universal and are essential for cell viability. The key to their usefulness lies in being able to find drugs that inhibit a pathogen synthetase but not its human cell counterpart. The ...
malate synthetase 苹果酸合成酶 peptide synthetase 【医】 肽合成酶, 肽酶 相似单词 aminoacyl 氨基酰; 氨酰基 tRNA n. =transfer RNA trna transfer RNA synthetase n. [生化]合成酶 tRNA methylase 转移核糖核酸甲基酶 N formylmethionyl tRNA N-甲酰蛋氨酰转移核糖核酸 最新...
百度试题 题目[名词解释] 氨酰-tRNA合成酶(aminoacyl-tRNA synthetase) 相关知识点: 试题来源: 解析 催化特定氨基酸激活并共价结合在相应的tRNA分子3ˊ端的酶。反馈 收藏
aminoacyl tRNA synthetase 网络 氨酰tRNA合成酶; 合成酶; 氨醯合成酵素; 氨基酰tRNA合成酶
Like HF, the threonyl-tRNA synthetase inhibitor borrelidin suppresses the induction of tissue remodeling and inflammatory mediators in cytokine-stimulated fibroblast-like synoviocytes without GCN2, but both aminoacyl-tRNA synthetase (aaRS) inhibitors are sensitive to the removal of GCN1. GCN1, an ...