Thus, the presence of D-AAs likely constitutes a bacterial adaptation to protect a vital cellular structure. Interestingly, this structural role can be therapeutically exploited, with the application of D-Ser in combination with beta-lactam antibiotics having a synergistic effect against MRSA by ...
Through the use of AFM, direct visualization of the adsorbed stabilizer directly on the drug surface would facilitate the elucidation of the extent of the interaction between the drug and the stabilizer and provides vital information about the characteristics of the adsorbed layer, such as the spe...
We showed the vital influence of our acids in controlling the diastereomeric outcome of the reaction simply by using a different catalyst substitution pattern. Moreover, this approach could be advanced to a practical and useful method to synthesize previously unknown N-Boc β3-amino acid methyl ...
Despite these important roles in vital metabolic processes, information on the interaction between collectrin/ACE2 and B0AT1 or B0AT3 is scarce. It is thought to involve a conserved Arg-240 residue in B0AT1 (Arg-225 in B0AT3) (7Kowalczuk S. Bröer A. Tietze N. Vanslambrouck J.M. R...
(idiographic) associations. This research makes use of an idiographic perspective to explore how subjective readiness and motives for LTPA relate with volitional energy (extent, powersee more) and affective experience (enjoyment, displeasure). We also highlight the potential for different interpretations...
Adaptation to low ambient temperature is one of the mechanisms vital to the survival of mammals. Undoubtedly, mammals need to expend more energy to cope with low temperature ( Yu et al., 2015 ). To date, since fatty acids and glucose are the main energy sources, most studies have focused...
Proteins are vital parts of living organisms, as they are the main components of most physiological pathways in cells. The term “proteomics” was coined to make an analogy with genomics, the study of genes. The word “proteome” is a portmanteau of “protein” and “genome”. The proteome...
With the growing interest in the field of proteomics, the amount of publicly available proteome resources has also increased dramatically. This means that there are many useful resources available for almost all aspects of a proteomics experiment. However, it remains vital to use the right resource...
This work solves a long-standing problem in the biology of nuclear transport and paves the way to decipher how other importin α isoforms recognize NLS cargos vital to cell physiology (e.g., STATs) or associated with disease states (e.g., Ebola virus p24). Methods Molecular biology ...
4c) and likely play a vital role in the catalysis of PikCH238pAcF towards the non-natural substrate 6. Compared with PikCWT, PikCH238pAcF showed a higher catalytic activity for 4 (Fig. 3e). In the crystal structure of 4-bound PikCH238pAcF (PDB ID code: 7XBN, 2.0 Å resolution,...