Role of calcium in structure and activity. Binding of various substrate analogues to the enzyme suggests that the amino acid residues involved in the catalytic reaction are a pair of aspartic acids... Buisson,Duée,Haser,... - 《Embo Journal》 被引量: 423发表: 1987年 Interstrand Side Chain?
In keeping with these results, mutation of Lys360, Val361, and Lys365 diminished strongly the DNA binding activity of hRARα as a homodimer or a heterodimer. Our results thus provide direct evidence for the differential involvement of basic, polar, or aromatic amino acids in the DNA binding,...
Hydrogen-bonding studies of amino acid side-chains with DNA base pairs[J] . P. Deepa,P. Kolandaivel,K. Senthilkumar.Molecular Physics . 2011 (16)Deepa P, Kolandaivel P, Senthilkumar K. Hydrogen bonding studies of Amino acid side chains with DNA base pairs. Mol Phys. 2011;109(16):...
Critical base pairs and amino acids residues for protein-DNA interaction between the TyrR protein...Presents a study which identifies the critical base pairs and amino acids needed for protein-DNA interaction between the TyrR protein and tyrP operator in Escherichia coli. Requirements for the ...
et al. Branched-chain amino acid-enriched nutrients stimulate antioxidant DNA repair in a rat model of liver injury induced by carbon tetrachloride. Mol. Biol. Rep. 39, 10803–10810 (2012). CAS PubMed Google Scholar Kuwahata, M. et al. Supplementation with branched-chain amino acids atten...
Aminoacylation is a two-step process in which amino acids are first activated by ATP, forming an intermediate aminoacyl adenylate, and then transferred to the 3′-end of tRNA to form the aminoacyl-tRNA end-product [2,3]. From:Trends in Molecular Medicine,2013 ...
The predicted protein sequence of 638 amino acids has substantial sequence similarity to the E. coli cysteinyl-tRNA synthetase in the nucleotide-binding fold region that constitutes the potential active site. The results are consistent with the hypothesis that evolution of the full complement of ...
In bacteria, branched-chain amino-acid aminotransferase (BCAT) catalyzes the last step of biosynthesis of branched-chain amino acids. Valine, leucine, and isoleucine are synthesized from the corresponding keto acids by amino-group transfer from glutamate. In , BCAT is encoded by the gene , which...
The types of amino acids that significantly contribute to evolutionary rates can be grouped into GC-rich and AT-rich amino acids. Besides, the amino acid with high composition also contributes more to evolutionary rates than amino acid with low composition in proteome. In summary, amino acid ...
Of 259 types of theoretical amino acid pairs in human CA54 protein, 67 types are randomly predictable and 192 are randomly unpredictable. As mentioned Discussion Currently two explanations are commonly proposed to explain why some amino acids are mutated more frequently than the others. The first ...