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Amino acid residues N450 and Q449 are critical for the uptake capacity and specificity of UapA, a prototype of a nucleobase-ascorbate transporter family. Amino acid residues N450 and Q449 are critical for the uptake capacity and specificity of UapA, a prototype of a nucleobase-ascorbate ...
two proteins commonly associated with nucleic acids (like DNA and RNA). So far, its main use was for newborns to excite new growth, because at a young age its difficult to manufacture enough.
Amino acids (AAs) are one of the primary metabolic substrates for cardiac work. The correlation between AAs and both atrial fibrillation (AF) and aging has been documented. However, the relationship between AAs and age-related AF remains unclear. Methods Initially, the plasma AA levels of persis...
Thus, there may be a need for new therapeutic targets to suppress lipogenesis. Branched-chain amino acids (BCAAs; leucine, isoleucine, and valine) are essential amino acids that must be acquired from the diet. To support sustained biomass accumulation, cancer cells require increased levels of ...
Many drug formulations containing small active molecules are used for the treatment of coronary artery disease, which affects a significant part of the wor
The absence of orthogonal aminoacyl-transfer RNA (tRNA) synthetases that accept non-l-α-amino acids is a primary bottleneck hindering the in vivo translation of sequence-defined hetero-oligomers and biomaterials. Here we report that pyrrolysyl-tRNA synt
D-serine has been shown to improve positive, negative, and cognitive symptoms when used as add-on therapy for the treatment of schizophrenia. However, D-serine has to be administered at high doses to observe clinical effects. This is thought to be due to
This amount was about 170% of the sum ammonia incorporated into all other amino acids (Fig. 1j). The ammonia consumed by arginine biosynthesis under MR would be even more because many nitrogen-containing intermediates, such as ornithine and citrulline, are generated in this biosynthetic pathway (...
Amino acids are considered the most critical regulator of mTORC1 because growth factors alone cannot activate the kinase efficiently during amino acid deprivation7. In addition to its role in promoting anabolic pathways, mTORC1 represses catabolic processes like macroautophagy (hereafter referred to as ...