of PEI-L were identified from a library of four-arm oligo(ethanamino)amides comprising the different PEI-related artificial oligoamino acids Gtt, Stp and Sph with varied length of the oligoamine segment, together with additional alanine (A), histidine (H) and cysteine (C) amino acids. Here...
This review is an attempt to illustrate the diversity of peptides reported for a potential or an established use in cancer therapy. With 612 references, this work aims at covering the patents and publications up to year 2000 with many inroads in years 2001–2002. The peptides are classed acc...
10. Inclusion Complexation of Modified β -Cyclodextrins with Amino Acids: Enhanced Enantioselectivity for L/D-Leucine. J. Org. Chem. 62, 1826–1830 (1997). 20. Kanagaraj, K., Suresh, P. & Pitchumani, K. Per-6-amino-β -cyclodextrin as a Reusable Promoter and Chiral Host for ...
The βARKct mice express the carboxyl-terminal 194 amino acids of GRK2 that competes for binding to Gβγ and membrane translocation, acting as a peptide inhibitor of GRK2 activity on GPCRs (Fig. 3A) [6]. Consistent with previous myocardial infarction studies, βARKct expression was ...
The protein quality of this organism suffered from the same deficiency that has become typical with single cell protein, the levels of sulfur amino acids are much too low for human consumption (McLaren, 1975; Tannenbaum & Mateles, 1968) . The level in Brevibacterium JM98A is only about 507...
Some of the Hcs exhibit a cytotoxic effect on cancer cells and do not affect or have a lower effect on the viability of normal cells [25–28]. We have found that ILs with cholinium or 1-ethyl-3-methylimidazolium cation and anions polar or hydrophobic amino acids induce changes in the ...
Synthesis of Substituted Quinazolinone Bearing Amino Acids (A–H) 3-amino 6-fluoro-2-(4-fluorophenyl)quinazolin-4(3H)-one (4), different Fmoc-protected L-amino acids and PyBOP in equimolar quantities (1 mmol) were dissolved in 30 mL anhydrous DMF. After fully dissolving, the reaction ...
System L plays a crucial role in placental transport of essential amino acids such as leucine and methionine and thus has been assumed to also transport MeHg-L-cysteine across the placenta. The uptake of methylmercury and tritiated leucine and methionine into the choriocarcinoma cell line BeWo was...
The residues depicted in sticks are helpful in giving a representation of the very high level of similarity among the ATP-binding pockets of the different PDK isoforms, which becomes absolute looking at the amino acids closest to the ligand. The residue Asn283 from PDK1 (labeled in green and ...
However, no hydrogen bonding is found for the dominant conformation to the neighboring amino acids as shown in Figure 6B. The other conformations were predicted to bind to PIM-1 via hydrogen bonds but consequently had a poorer fit in the pocket. 2.6. Chemical Space The calculated molecular ...