Demonstration of the UAA ochre codon in bakers yeast by amino-acid replacements in iso-1-cytochrome c. J Mol Biol. 1972 Jul 14; 68 (1):83–96.STEWARTJ,., F. SHERMANM, . JACKSOFN.,THOMAanSd N. SHIPMAN,1972 Demonstration of the UAA ochre codon in baker's yeast by amino-acid ...
The ratio of radical to conservative amino acid replacements is frequently used to infer positive Darwinian selection. This method is based on the assumption that radical replacements are more likely than conservative replacements to improve the function of a protein. Therefore, if positive selection pl...
The conjugation of amino acids linked by peptide bonds offers the polymer biodegradability and often biocompatibility [2]. The former offers poly(amino acid)s significance as replacements for PEG, which is not readily biodegradable in vivo. In addition, the functional group that the starting amino ...
with disparate physicochemical properties, e.g. hydropathy or polarity. To verify hypotheses if mutational pressures operating in various bacterial genomes are random or they are optimized in respect of amino acid replacements in products of protein-coding genes, we compared the empirical mutational pres...
Plastid-localized amino acid biosynthetic pathways of Plantae are predominantly composed of non-cyanobacterial enzymes Adrian Reyes-Prieto1* & Ahmed Moustafa2* 1Canadian Institute for Advanced Research and Department of Biology, University of New Brunswick, Fredericton, Canada, 2Department of Biology and...
During the half century following its discovery, the l-glutamate-producing microorganism Corynebacterium glutamicum has played a leading role in the amino acid fermentation industry. Due to its importance as an amino acid producer, C. glutamicum is also one of the best-investigated microorganisms, evi...
Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens. Genome Res. 2003; 13(7):1572–9. 10. Musto H, Naya H, Zavala A, Romero H, Alvarez-Valin F, Bernardi G. Correlations between genomic GC levels and ...
contrary to other amino acids and primary metabolites, the artificial channelling of building blocks from central metabolism towards the aromatic amino acid pathway is complicated to achieve in an efficient manner. The length and complex regulation of this pathway have progressively called for the employ...
1). He aimed at an improved description of amino acid relatedness in protein sequence alignments. Taylor’s classification has been particularly useful in its interpretability because he only used measures easy to understand as, for example, polarity and hydrophobicity. Furthermore, the Euler diagram...
Bain et al., “Ribosome-mediated incorporation of a non-standard amino acid into a peptide through expansion of the genetic code”, Nature, 1992, 356(6369): 537-539. Bain, J.D. et al., “Biosynthetic site-specific incorporation of a non-natural amino acid into a polypeptide”, J. Am...