Amino acid metabolismCancer stem cellSelf-renewalResistanceCancer stem cells(CSCs) possess self-renewal and differentiation potential, which may be related to recurrence, metastasis, and radiochemotherapy resistance during tumor treatment. Understanding the mechanisms via which CSCs maintain self-renewal may...
In addition, it examines situations when amino acid synthesis is driven through metabolic coupling to other reactions, and synthesis is in excess of the cancer cell's proliferative demand. Finally, it highlights the understudied area of non-proteinogenic amino acids in cancer metabolism and their ...
Reprints and permissions About this article Cite this article Peng, H., Wang, Y. & Luo, W. Multifaceted role of branched-chain amino acid metabolism in cancer.Oncogene39, 6747–6756 (2020). https://doi.org/10.1038/s41388-020-01480-z ...
cancer metabolism has focused on central carbon metabolism, including glycolysis and the tricarboxylic acid cycle (the citric acid cycle, TCA cycle). However, new studies
the important role of amino acids in cancer metabolism. Amino acids also serve the essential purposes of redox balance, energetic regulation, biosynthetic support, and homeostatic maintenance. This wide breadth of metabolic activities has made amino acid metabolism increasingly popular in cancer research....
Here, we discovered an unanticipated mechanism of crosstalk between altered growth factor receptor signaling and glutamate-cystine metabolism in tumor cells, linking growth factor receptor signaling with amino acid metabolism in cancer. Results Unbiased Screen Identifies mTORC2 as a Binding Partner of xCT...
2.5.3 Amino acid metabolism Amino acid metabolism is crucial for the survival of cancer cells, as amino acids act as precursors for the biosynthesis of nucleotides, lipids, and other essential biomolecules. In OS cells, AMPK signaling can regulate amino acid metabolism by influencing the expression...
Amino acid metabolism plays important roles in tumor biology and tumor therapy. Accumulating evidence has shown that amino acids contribute to tumorigenesis and tumor immunity by acting as nutrients, signaling molecules, and could also regulate gene tran
Protein and Amino Acid Metabolism in Cancer Cachexia: Investigative Techniques and Therapeutic Interventions Cancer cachexia is a complex syndrome characterized primarily by diminished nutrient intake and progressive tissue depletion that is manifest clinically as... PWT Pisters,DB Pearlstone,MH Toroslan -...
mTOR signalling and cellular metabolism are mutual determinants in cancer. Nat. Rev. Cancer 18, 744–757 (2018). PubMed Google Scholar Cormerais, Y. et al. Genetic disruption of the multifunctional CD98/LAT1 complex demonstrates the key role of essential amino acid transport in the control ...